June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Global versus localized association of reticular pseudodrusen with relative ellipsoid zone reflectivity in intermediate age-related macular degeneration
Author Affiliations & Notes
  • Sarah Thiele
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
    Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, Gloucestershire, United Kingdom
  • Charlotte Behning
    Institute of Medical Biometry, Informatics and Epidemiology, Universitatsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Yannick Liermann
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Marlene Sassmannshausen
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Leonie Weinhold
    Institute of Medical Biometry, Informatics and Epidemiology, Universitatsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Ben Isselmann
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Matthias Schmid
    Institute of Medical Biometry, Informatics and Epidemiology, Universitatsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Robert P Finger
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Steffen Schmitz-Valckenberg
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Maximilian Pfau
    Institute of Molecular and Clinical Ophthalmology Basel, Basel, Basel-Stadt, Switzerland
  • Chi D Luu
    Center for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
    Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
  • Frank G Holz
    Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
  • Footnotes
    Commercial Relationships   Sarah Thiele Carl Zeiss Meditec, CenterVue, Heidelberg Engineering, Optos, Novartis, Code F (Financial Support), Allergan, Bayer, Heidelberg Engineering, Novartis, Code R (Recipient); Charlotte Behning None; Yannick Liermann Carl Zeiss MedicTec AG, CenterVue, Heidelberg Engineering, Code F (Financial Support); Marlene Sassmannshausen Carl Zeiss MedicTec AG, CenterVue, Heidelberg Engineering, Code F (Financial Support); Leonie Weinhold None; Ben Isselmann None; Matthias Schmid None; Robert Finger Alimera, Apellis, Bayer, Böhringer-Ingelheim, Novartis, ODOS, Oxford Innovation, ProGenerika, Roche/Genentech, Code C (Consultant/Contractor), Biogen, CentreVue (now Icare), Heidelberg Engineering, Zeiss Meditec, Code F (Financial Support); Steffen Schmitz-Valckenberg AlphaRET, Apellis, Bioeq, Katairo, Kubota Vision, Novartis, Pixium, Roche, SparingVision , Code C (Consultant/Contractor), Bayer, Heidelberg Engineering, Novartis, Roche, Code F (Financial Support), GRADE Reading Center, Code O (Owner), Apellis, Heidelberg Engineering , Code R (Recipient); Maximilian Pfau None; Chi Luu None; Frank Holz Acucela, Alexion, Alzheon, Apellis, Astellas, Bayer, Boehringer-Ingelheim, Bioeq/Formycon, Roche/Genentech, Geuder, Graybug, Gyroscope, Heidelberg Engineering, IvericBio, Janssen, Kanghong, LinBioscience, Novartis, Oxurion, Pixium Vision, Stealth BioTherapeutics, Zeiss , Code C (Consultant/Contractor), Acucela, Allergan, Apellis, Bayer, Bioeq/Formycon, CenterVue, Roche/Genentech, Geuder, Heidelberg Engineering, IvericBio, Kanghong, NightStarX, Novartis, Optos, Pixium Vision, Zeiss , Code F (Financial Support), GRADE Reading Center, Code O (Owner)
  • Footnotes
    Support  German Research Foundation (TH 2514/2-1)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4326. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sarah Thiele, Charlotte Behning, Yannick Liermann, Marlene Sassmannshausen, Leonie Weinhold, Ben Isselmann, Matthias Schmid, Robert P Finger, Steffen Schmitz-Valckenberg, Maximilian Pfau, Chi D Luu, Frank G Holz; Global versus localized association of reticular pseudodrusen with relative ellipsoid zone reflectivity in intermediate age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4326.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The relative ellipsoid zone reflectivity (rEZR) is an indicator for outer retinal integrity on spectral-domain optical coherence tomography (SD-OCT). In global (eye level) analyses, reticular pseudodrusen (RPD) are cross-sectionally associated with a more reduced rEZR in intermediate age-related macular degeneration (iAMD) eyes. Further, rEZR decreases over time more rapidly in eyes with vs. without RPD. This study aimed to assess the spatial impact of RPD on the rEZR.

Methods : The rEZR [arbitrary units, AU] was determined in raw SD-OCT volume scans (241 B-scans, field size 30°x25°) from baseline visit of the MACUSTAR study. RPDs’ presence topographical information was obtained by its area’s manual annotation in infrared imaging. Other iAMD features, including pigmentary abnormalities (PA) and the RPEDC volume were also determined. Linear mixed-effects models with the rEZR as the dependent variable were applied to evaluate the impact of global vs. spatial vs. global+spatial RPD presence on the localized rEZR (with covariates adjusting for age and eccentricity).

Results : A total of 164 eyes of 164 patients (mean±SD age: 71.3±7.52 years) of the iAMD MACUSTAR study cohort were included. The global presence of RPD was associated with a reduced rEZR of -6.45 AU (95%-CI: -12.24;-0.67 [p=0.029]). The presence of PA was also associated with an rEZR reduction (-3.91 AU [-8.52;0.71 (p=0.097)] as well as an RPEDC volume [mm3] increase (-2.49 AU [-39.23;34.24 (p=0.894)]. Considered topographically, RPD exhibited an association with the rEZR of -11.74 AU (-11.90;-11.58 [p<0.001]), the RPEDC volume of -1.87 AU (-38.15;34.40 [p=0.919]) and the presence of PA of -4.26 AU (-8.79;0.28 [p=0.066]). Taken further the global and topographical RPD presence simultaneously into account, only RPD were shown to exhibit an association with the rEZR when considered topographically as demonstrated by an rEZR decrease of -11.74 AU (-11.90;-11.58 [p<0.001]).

Conclusions : The rEZR exhibited a significant association with the presence of RPD, a high-risk structural phenotype for AMD progression. This was even more pronounced when the topographical information of RPD within an eye was also taken into account. Ongoing studies assess the prognostic value of the rEZR for progression to late-stage AMD manifestations.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×