June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Effect of intraoperative application of chemically defined bioadhesive powder to prevent scar formation after trabeculectomy in rabbit eyes.
Author Affiliations & Notes
  • Yoshifumi Okamoto
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
    Ophthalmology, Mito Kyodo Byoin, Mito, Ibaraki, Japan
  • Sujin Hoshi
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
  • Mikki Arai
    Ophthalomology, Arai Eye Clinic, Fukuoka, Japan
  • Fumiki Okamoto
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
  • Yuki Gen
    BMG Incorporated, Kyoto, Japan
  • Suong-Hyu Hyon
    BMG Incorporated, Kyoto, Japan
  • Masato Sugano
    Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa-city, Chiba, Japan
  • Kuniharu Tasaki
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
  • Tomoya Murakami
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
  • Tetsuro Oshika
    Ophthalmology, University of Tsukuba, Tsukuba-city, Ibaraki, Japan
  • Footnotes
    Commercial Relationships   Yoshifumi Okamoto None; Sujin Hoshi None; Mikki Arai None; Fumiki Okamoto None; Yuki Gen None; Suong-Hyu Hyon None; Masato Sugano None; Kuniharu Tasaki None; Tomoya Murakami None; Tetsuro Oshika None
  • Footnotes
    Support  22675838
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4280. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yoshifumi Okamoto, Sujin Hoshi, Mikki Arai, Fumiki Okamoto, Yuki Gen, Suong-Hyu Hyon, Masato Sugano, Kuniharu Tasaki, Tomoya Murakami, Tetsuro Oshika; Effect of intraoperative application of chemically defined bioadhesive powder to prevent scar formation after trabeculectomy in rabbit eyes. . Invest. Ophthalmol. Vis. Sci. 2023;64(8):4280.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the effect of chemically defined bioadhesive (CDB) powder, containing dextran and polylysine, in preventing postoperative tissue adhesion following trabeculectomy in rabbit eyes.<div id="accel-snackbar" style="left: 50%; transform: translate(-50%, 0px); top: 50px;"> </div>

Methods : In six rabbit eyes, trabeculectomy was performed with a 3*3-mm scleral flap and fornix-based conjunctival incision. In three eyes, CDB powder was applied under the conjunctiva and scleral flap, which was gelled by dropwise addition of a balanced salt solution (CDB group). Three eyes served as a control group (non-CDB group). Slit-lamp examination, intraocular pressure (IOP) measurement, and anterior segment optical coherence tomography (AS-OCT) were performed at day 7, and 1, 2, and 4 months postoperatively. The eyes were enucleated for histological evaluation at 4 months postoperatively.<div id="accel-snackbar" style="left: 50%; transform: translate(-50%, 0px); top: 50px;"> </div>

Results : A smooth bleb without significant inflammation or adhesion was formed by the gelled CDB, and the AS-OCT revealed the bleb formation for up to 4 months. In contrast, the bleb collapsed at 1 month postoperatively in the control group. The postoperative IOP in the CDB group tended to be lower than that of the control group, however without a statistically significant value. The histological examination did not reveal excess connective tissue or collagen fibers in the CDB group compared to the control group.<div id="accel-snackbar" style="left: 50%; transform: translate(-50%, 0px); top: 50px;"> </div>

Conclusions : CDB powder was effective in inhibiting postoperative adhesion formation after trabeculectomy for 4 months in rabbit eyes. CDB can be a candidate for adhesion preventing material in filtration surgery.<div id="accel-snackbar" style="left: 50%; transform: translate(-50%, 0px); top: 50px;"> </div>

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×