June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The Ganglion Cell Layer in Myopia.
Author Affiliations & Notes
  • Vinay Nangia
    Suraj Eye Institute, Nagpur, Maharashtra, India
  • Ravi Daberao
    Suraj Eye Institute, Nagpur, Maharashtra, India
  • Prabhat Nangia
    Suraj Eye Institute, Nagpur, Maharashtra, India
  • Sarang Lambat
    Suraj Eye Institute, Nagpur, Maharashtra, India
  • Footnotes
    Commercial Relationships   Vinay Nangia None; Ravi Daberao None; Prabhat Nangia None; Sarang Lambat None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4149. doi:
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    • Get Citation

      Vinay Nangia, Ravi Daberao, Prabhat Nangia, Sarang Lambat; The Ganglion Cell Layer in Myopia.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4149.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Myopia is a significant risk factor for glaucomatous damage. The ganglion cell layer (GCL) is useful in the diagnosis and follow-up of glaucoma. It was the purpose to study the GCL thickness in myopia and its correlations.

Methods : 160 eyes of 93 (64 female) myopic subjects without glaucoma were included. Besides an ophthalmic evaluation, all subjects underwent SDOCT to determine the GCL thickness. The macula GCl thickness and percentile values for global and for superior (S), temporal superior (TS), temporal inferior (TI), inferior, nasal inferior (NI) and nasal superior (NS) sectors were obtained.

Results : The mean age was 30±13.58 yrs. The mean spherical equivalent was -5.80±3.36D, mean axial length was 25.54±1.56 mm. The mean IOP was 15.59±2.41 mmHg. The mean GCL thickness values were for global, 48.46±6.02 um, superior 50.40±5.60um, TS, 44.72±6.58um, TI, 47.61±6.92um, inferior 49.73±6.32, NI 49.76±6.09um and NS 49.78±6.59 um. The global percentile values within normal limits (>5%) were seen in 107 eyes, Borderline (<5%) in 30 eyes and outside normal limits of (<1%) in 23 eyes. Outside normal limits, values were seen most in the nasal inferior (30 eyes), followed by the nasal superior sector (29 eyes). On bivariate analysis, negative significant correlations were seen of the global GCL thickness values with age (p<0.001;r=-0.407), axial length (p=0.003;r=-0.231), category of myopic maculopathy (p=0.05;r=-0.223) total clock hours and maximum width of parapapillary atrophy (p=0.005;r=-0.222 and p=<0.001;r=-0.333) respectively. A positive significant correlation was seen with the spherical equivalent (p=0.002;r=0.240) and anterior chamber depth (p=0.022;r=0.181). Multivariate analysis with the global GCL thickness as the dependent variable and all significant parameters mentioned above as independent variables showed a negative significant correlation only with age (P=0.030).

Conclusions : The GCL values were thickest in the superior and thinnest in the TS sector. A significant negative correlation was seen with axial length, indicating that an increase in axial length is associated with thinning of GCL. On multivariate analysis, there was a significant correlation with age, indicating progressive thinning of the GCL with increasing age in myopia. The finding that a significant number of myopes have lower percentile values of <5% and <1%) should be considered while diagnosing glaucoma in myopia.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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