June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Swept-source anterior segment OCT in dry eye, ocular surface disease and healthy eyes: a repeatability study of quantitative measurements
Author Affiliations & Notes
  • Alberto Recchioni
    Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, Birmingham, United Kingdom
    Birmingham and Midland Eye Centre, Birmingham, Birmingham, United Kingdom
  • Saaeha Rauz
    Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, Birmingham, United Kingdom
    Birmingham and Midland Eye Centre, Birmingham, Birmingham, United Kingdom
  • Abinaya Priya Venkataraman
    Clinical Neuroscience, Karolinska Institutet, Stockholm, Stockholm, Sweden
  • Alberto Dominguez-Vicent
    Clinical Neuroscience, Karolinska Institutet, Stockholm, Stockholm, Sweden
  • Footnotes
    Commercial Relationships   Alberto Recchioni None; Saaeha Rauz None; Abinaya Priya Venkataraman None; Alberto Dominguez-Vicent None
  • Footnotes
    Support  II-LA-1117-20001 Programme Invention for Innovation (i4i), National Institute for Health Research (NIHR)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4020. doi:
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      Alberto Recchioni, Saaeha Rauz, Abinaya Priya Venkataraman, Alberto Dominguez-Vicent; Swept-source anterior segment OCT in dry eye, ocular surface disease and healthy eyes: a repeatability study of quantitative measurements. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4020.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Dry eye and ocular surface disease (OSD) are the most common causes of eye discomfort with up to 50% of the global population affected. Anterior segment optical coherence tomography (AS-OCT) is essential to diagnose and track ocular surface changes. This study aims at assessing the precision of a modern swept source AS-OCT in OSD vs healthy control.

Methods : Six clinical groups were included: G1=Sjögren’s syndrome (n=50); G2=Ocular Mucous Membrane Pemphigoid, Graft-versus-Host Disease, etc. (n=60); G3=Meibomian Gland Disease (n=61); G4= Corneal Transplant (n=17); G5=Miscellaneous (Neurotrophic, Trauma, Exposure, Inherited, etc.) (n=12); G6= healthy controls (n=40). Three consecutive measurements using a radial scan mode were collected using the AS-OCT Casia2 (Tomey, Japan) and the repeatability limits (RLs) were calculated. The following parameters were obtained: anterior chamber depth (ACD), AC width (ACW), angle opening distance (AOD) and angle recess area (ARA) both at 250, 500 and 750 µm, angle to angle (ATA), central thickness apex (CTapex), central thickness thin (CTthin), anterior keratometry flat meridian (Kf), anterior keratometry steep meridian (Ks), lens vault (LV), trabecular iris angle (TIA) and trabecular iris-space area (TISA) both at 250, 500 and 750 µm. Dry eye metrics such as OSDI® questionnaire, fluorescein break-up time (FBUT), tear meniscus height (TMH), conjunctival inflammation (INFLCONJ) and ocular surface staining (OSS) were considered.

Results : The higher RLs values were observed within the G4 cohort considering AOD (0.24,0.31,0.34 vs G6 0.19,0.18,0.25 mm), ARA (0.09,0.15,0.22 vs G6 0.06,0.10,0.14 mm2), CTthin (8.01 vs G6 4.67 µm), and TISA (0.05,0.12,0.19 vs G6 0.04,0.08,0.13 mm2). G1 cohort reported the worst dry eye metrics (OSDI 52.90±20.58 score, FBUT 3.51±2.36s, TMH 0.10±0.07mm, INFLCONJ 1.07±1.78 score, OSS 4.27±2.35 score).

Conclusions : This is the first study to consider anterior segment analysis repeatability limits in OSD vs healthy cohorts with the AS-OCT Casia2. Despite G1 Sjögren’s syndrome cohort reported the worse dry eye metrics, the higher repeatability limits were observed in the G4 Corneal Transplant group.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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