Abstract
Purpose :
To describe the relationship between serum glucose and lipids with serum total testosterone (TT), dehydroepiandrosterone (DHEA), and Meibomian gland disfunction (MGD).
Methods :
This was a cross-sectional, observational, and descriptive study involving people between 20 to 40 years. Diet evaluations were made by a nutritionist to find out their habitual lipids and carbohydrates consumption. Blood workup for TT, DHEA, estradiol, glucose, cholesterol, and triglycerides was studied. MGD was determined through meibum quality, superficial punctate keratitis, symptoms measured by OSDI questionnaire, and tear break up time. Statistical analysis was done using SPSS 21 R-squared test.
Results :
In men, fasting serum glucose had statistical correlation with TT concentration (R2 0.441, p = 0.007), besides, those between 20 to 29 years had significant correlations with DHEA (R2 0.549, p = 0.035). For women, glucose had statistical correlation with TT concentration in ages between 30 to 40 years (R2 0.617, p = 0.021). MGD had significant correlation with TT (R2 0.405, p = 0.011) in men, and with DHEA (R2 0.37, p = 0.016) in women. Additionally, men had significant correlation between lipids intake and MGD (R2 0.305, p = 0.01), and in women a tendency was also observed (R2 0.207, p = 0.077).
Conclusions :
Fasting serum glucose had a significant statistical correlation with TT concentrations in both genders, and with DHEA in men. Meibomian gland disfunction had significant correlation with TT concentration in men, and with DHEA in women.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.