2-Year Multi-Site Observational Study of MiYOSMART myopia control spectacle lenses in UK children: 1-year results

Abstract

Purpose : MiYOSMART spectacles lenses are well tolerated and effectively retard myopia in Chinese children (8-13 years) compared to peers in conventional spectacle lenses. We present data on change in SER and AL from the first 12-months of a 2-year observational study which explores MiYOSMART's tolerability, efficacy, and the impact of age on efficacy for children in the UK.

Methods : Recruits aged 5-15 years (cycloplegic spherical equivalent refraction [SER] -0.50 to -8.50D, anisometropia ≤1.50D and astigmatism ≤2.50D) were prescribed MiYOSMART spectacle lenses. SER (cycloplegic autorefraction) and axial length (AL, IOLMaster) were measured at baseline and after 6- and 12-months. Change in SER and AL over 12-months was compared with UK myopic control data of similar age (8-13 years) and ethnicity (12-month change in SER=-0.58D, AL=0.24mm, Chamberlain et al. 2019) and age specific models of untreated myopic annual AL growth from non-Asian studies (9 years 0.38mm, 13 years 0.19mm, Shamp et al. 2022).

Results : Participants were 87 children mean ±SD age 10.3 ±2.4 years (65% White, 18% Indian Asian, 8% Other Asian, 6% Chinese, 3% Other). Mean ±SD 12-month change in SER and AL were -0.36±0.42D and 0.18±0.20mm respectively, significantly less than reported for untreated UK myopes by Chamberlain et al. 2019 (SER: t=4.82, p=0.0001; AL: t=-2.80, p=0.003). Younger children (<10 years, mean 8.1 years at baseline) showed significantly more myopic progression (-0.56D vs -0.22D; t=-4.12, p=0.0001) and AL increase over 12-months (0.32mm vs 0.08mm; t=7.22, p<0.0001) than those age 10-15 years (mean 12.0 years at baseline). Compared to expected 12-month growth for children aged 9 and 13 years, MIYOSMART significantly reduced axial elongation by 15% and 57% in younger (<10 years, t=-1.99, p=0.027) and older (10-15 years, t=-6.04, p<0.0001) children respectively. 12-month change in SER was restricted to -0.25D or less in 19% and 54% of children in the younger and older groups respectively.

Conclusions : Compared to published data from untreated myopes, MiYOSMART spectacle lenses significantly reduced average myopic progression and axial elongation in UK children. Better efficacy was seen in children over 10 years of age.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.