June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Refractive error following endoscopic vitrectomy for stage 4 retinopathy of prematurity
Author Affiliations & Notes
  • Katie Williams
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
    Section of Academic Ophthalmology, King's College London, London, London, United Kingdom
  • James Wawrzynski
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
    University College London, London, London, United Kingdom
  • Elisabeth De Smit
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
  • Christopher J Hammond
    Section of Academic Ophthalmology, King's College London, London, London, United Kingdom
  • Chetan Kantibhai Patel
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
  • Robert Henderson
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
    University College London, London, London, United Kingdom
  • Sui Chien Wong
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Katie Williams None; James Wawrzynski None; Elisabeth De Smit None; Christopher Hammond None; Chetan Patel None; Robert Henderson None; Sui Chien Wong DORC, Code C (Consultant/Contractor), BVI, Code C (Consultant/Contractor)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4931. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Katie Williams, James Wawrzynski, Elisabeth De Smit, Christopher J Hammond, Chetan Kantibhai Patel, Robert Henderson, Sui Chien Wong; Refractive error following endoscopic vitrectomy for stage 4 retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4931.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To examine refractive error in a consecutive cohort of children undergoing endoscopic vitrectomy for stage 4 retinopathy of prematurity (ROP). It is known that myopia, as a result of severe ROP and retinal laser for ROP, is common but refractive outcomes following endoscopic vitrectomy are less well understood.

Methods : Prospective cohort of all infants in the UK undergoing endoscopic vitrectomy for tractional retinal detachment in ROP (stage 4). Inclusion criteria for this study was cycloplegic refraction at follow-up. Those undergoing lensectomy or noted to have lens opacity were excluded. Prior or concurrent treatment with retinal laser or intravitreal anti-VEGF was recorded. Spherical equivalent (SE) was calculated using the standard formula (sphere + cylinder/2) at most recent refraction. Median SE and absolute SE difference between right and left eye was examined.

Results : We identified 18 patients (55% male) with a mean gestational age of 25.8 weeks. Fifty percent underwent bilateral vitrectomy (n=9), fifty percent unilateral vitrectomy (right=5, left=4). In bilateral cases, 16 eyes were stage 4A and 2 eyes were stage 4B, with all except for 3 eyes (n=2 patients) receiving retinal laser. In unilateral vitrectomy cases 78% were stage 4A and 22% stage 4B, with stage 3 in majority of fellow eyes (78%) and bilateral retinal laser in all except one child who only underwent laser in the non-vitrectomy eye. Median SE in vitrectomy eyes was -8.06D (IQR -11.75 to -7.38) and -4D (IQR -6 to -0.75) in non-vitrectomy eyes at a median age of 1.7 years (IQR 1.5–3.5). There was a statistically significant greater interocular SE difference between those undergoing unilateral vs bilateral vitrectomy (6.88D vs 1.50D, p=0.005) - in unilateral cases 66% had interocular SE difference of >5D.

Conclusions : We confirm the high prevalence of myopia in stage 4 ROP treated with endoscopic vitrectomy. An interesting observation was those undergoing unilateral vitrectomy had a significantly higher myopic refractive error than fellow eye compared to bilateral cases. Whilst stage of ROP was generally higher in these eyes, the possible relationship between a vitrectomy in early life and increased myopia risk is intriguing. This could provide new insights into myopia development and ocular growth. Further research examining long-term refractive outcomes and ocular biometry in this population is required.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×