Abstract
Purpose :
Evaluate risk of developing steroid-induced ocular hypertension/glaucoma with long-term use of topical prednisolone acetate 1%
Methods :
Retrospective review of 211 patients without prior glaucoma,. Patients were treated with topical prednisolone acetate 1% to prevent to graft rejection following Descemet stripping endothelial keratoplasty . The main outcomes were ocular hypertension (defined as intraocular pressure increase of ≥ 10 mm Hg over baseline or ≥ 24 mm Hg regardless of baseline) and diagnosis of glaucoma.
Results :
Median follow-up was 7 years. At 1, 5 and 10 years, the cumulative risk of ocular hypertension atributed to corticosteroids was 29%, 41%, and 49%. At 1, 5 and 10 years, the cumulative risk of open-angle glaucoma attributed to steroids was 11%, 17%, and 25%.
Conclusions :
Long-term use of topical corticosteroids confers substantial risk of steroid-induced ocular hypertension/glaucoma. Patients who previously tolerated steroids without complication for years can development ocular hypertension and glaucoma as late as 10 years after starting steroids, inidicating a need for continued follow-up and intraocular pressure checks even without changes in steroid regimen.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.