June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
A comparison of endothelial and penetrating keratoplasty in patients with iridocorneal endothelial syndrome: a registry study
Author Affiliations & Notes
  • Philipp Roberts
    Ophthalmology, Medizinische Universitat Wien, Vienna, Vienna, Austria
    Ophthalmology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Miriam Keane
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Gink Yang
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
  • Elsie Chan
    Ophthalmology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Damien Harkin
    Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia
  • Natalie McKirdy
    Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia
  • Mark Daniell
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
    Ophthalmology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Philipp Roberts None; Miriam Keane None; Gink Yang None; Elsie Chan None; Damien Harkin None; Natalie McKirdy None; Mark Daniell None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4790. doi:
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      Philipp Roberts, Miriam Keane, Gink Yang, Elsie Chan, Damien Harkin, Natalie McKirdy, Mark Daniell; A comparison of endothelial and penetrating keratoplasty in patients with iridocorneal endothelial syndrome: a registry study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4790.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare graft survival of endothelial keratoplasty (EK) versus penetrating keratoplasty (PK) in patients with iridocorneal endothelial (ICE) syndrome and identify ocular features associated with graft survival.

Methods : A total of 30,806 first grafts performed between 1985 and 2020 were identified through the Australian Corneal Graft Registry and included in this observational, prospective cohort study. 196 eyes underwent a primary corneal graft for ICE syndrome. Kaplan-Meier graft survival plots and Chi-squared tests were performed to identify graft survival rates for EK and PK. A history of raised intraocular pressure (IOP) was recorded and analysed. Additionally, graft survival of eyes with ICE syndrome were compared to that of other indications.

Results : Grafts performed for ICE syndrome increased from 0.5% between 1985 to 2004 to 0.8% of all cases during the 2005 to 2020 period (Chi square=9.35, p=0.002). From 2010, EK surpassed PK as the preferred graft type. Survival of primary grafts in eyes with ICE syndrome was lower than for other indications (Chi square=56.62, p<0.001). Graft survival was higher following PK than Descemet stripping (automated) endothelial keratoplasty (DS(A)EK) (Chi square=10.56, p=0.001). Graft survival was higher in eyes without a history of raised IOP compared to those with a reported history of raised IOP (Chi square=13.06, p<0.001).

Conclusions : ICE syndrome carries a poor prognosis for graft survival. DS(A)EK had a poorer prognosis than PK. A history of raised IOP is associated with higher risk of graft failure.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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