Abstract
Purpose :
To describe the histopathologic characteristic of extravasated silicone oil in the ocular adnexae including the conjunctiva, orbit and eyelid.
Methods :
The database at the Florida Lions Ocular Pathology Laboratory was searched for surgical specimens at the Bascom Palmer Eye Institute under approval of the institutional review board. Patients with a diagnosis of extraocular “silicone oil” on pathology between the years of 1997 and 2022 from the Florida Lions Ocular Pathology laboratory database were included (n=24). Patient demographics (age and gender), anatomic site, laterality, and clinicopathologic features were evaluated.
Results :
The diagnosis of extraocular silicone oil extravasation was established by light microscopic examination of formalin fixed, paraffin embedded tissue in 24 eyes (Right=10, Left=14). From this group of 24 patients, 18 were male and 6 were female. The mean age was 39.6 years (Range: 8-65). Eighteen lesions were present in the conjunctiva (75%), three lesions in the orbit (12.5%), two in the eyelid (8.3%) and one in Tenon’s capsule (4.2%). All 24 cases (100%) demonstrated histiocytes with clear dropout spaces and positive CD68 immunohistochemical staining. Pertinent clinical histories included surgery for Coat’s disease, ocular trauma, and retinal detachment secondary to diabetic retinopathy.
Conclusions :
Silicone oil extravasation into the ocular adnexae including the conjunctiva, orbit and eyelid after vitrectomy surgery may occur and has distinct clinicopathologic findings. Clinicians and pathologists should be aware of these findings so as to aid in diagnosis and treatment.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.