June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Macular and optic nerve head vascular densities are reduced in patients with pre-perimetric primary open angle glaucoma
Alice Chandra Verticchio Vercellin; Alon Harris; Brent A Siesky; Julia Arciero; Brendan Fry; Francesco Oddone; George Eckert; Paul A Sidoti; Gal Antman; Aditya Belamkar; Louis R Pasquale
Author Affiliations & Notes
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alon Harris
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brent A Siesky
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Julia Arciero
    Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States
  • Brendan Fry
    Department of Mathematics and Statistics, Metropolitan State University of Denver, Denver, Colorado, United States
  • Francesco Oddone
    Glaucoma Unit, IRCCS Fondazione Bietti, Rome, Italy
  • George Eckert
    Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Paul A Sidoti
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Gal Antman
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Ophthalmology, Rabin Medical Center, Petah Tikva, Central, Israel
  • Aditya Belamkar
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Louis R Pasquale
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Alice Chandra Verticchio Vercellin None; Alon Harris AdOM, Qlaris, Luseed, Cipla , Code C (Consultant/Contractor), AdOM, Luseed, Oxymap, Qlaris, Phileas Pharma, SlitLed, QuLent , Code I (Personal Financial Interest), AdOM, Qlaris, Phileas Pharma , Code S (non-remunerative); Brent Siesky None; Julia Arciero None; Brendan Fry None; Francesco Oddone None; George Eckert None; Paul Sidoti None; Gal Antman None; Aditya Belamkar None; Louis Pasquale Eyenovia, Twenty Twenty, Skye Biosciences, Code C (Consultant/Contractor)
  • Footnotes
    Support  NIH grant (R01EY030851); NSF DMS (1853222/2021192); NYEE Foundation grants; in part by a Challenge Grant award from Research to Prevent Blindness, NY; NSF DMS-1654019; NSF DMS-1852146; NSF DMS-2150108; EY015473; EY032599
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4728. doi:
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      Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, Julia Arciero, Brendan Fry, Francesco Oddone, George Eckert, Paul A Sidoti, Gal Antman, Aditya Belamkar, Louis R Pasquale; Macular and optic nerve head vascular densities are reduced in patients with pre-perimetric primary open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4728.

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Abstract

Purpose : To investigate differences in macular and optic nerve head (ONH) vessel densities (VD) and structural parameters assessed by optical coherence tomography angiography (OCTA) in pre-perimetric open-angle glaucoma (ppOAG) patients versus healthy controls.

Methods : In a prospective cross-sectional analysis, 105 healthy and 78 pre-perimetric OAG patients with structural defects underwent visual field (VF) testing (Humphrey) and OCTA (Optovue) assessment of retinal and ONH structure, ganglion cell complex (GCC) thickness, and VD. Comparisons between ppOAG and healthy subject outcomes were adjusted for age, sex, race, BMI level, diabetes, high blood pressure/hypertension with p<0.05 considered statistically significant.

Results : GCC thickness (in microns) was significantly lower in ppOAG patients compared to controls (average: 95.4 (7.0) vs. 85.0 (15.6); p<0.001); (superior: 94.9 (8.0) vs. 83.7 (11.6); p<0.001); (inferior: 95.8 (7.4) vs. 86.3 (27.5); p<0.001). Global retinal nerve fiber layer (RNFL) thickness (in microns) was significantly lower in patients with OAG (80.7 (11.7) vs controls (101.7 (8.6); p<0.001) while cup to disc vertical ratio was higher in ppOAG patients (0.72 (0.15) vs. 0.47 (0.16); p=0.043). ONH whole image blood vessels and peripapillary VD were significantly lower in ppOAG patients versus controls (49.3 (2.5) vs. 44.0 (4.5); p<0.001) and (51.9 (3.1) vs. 45.7 (6.0); p<0.001). Biomarkers of macular thickness and VDs were also significantly lower in all quadrants of ppOAG patients compared to healthy controls (p<0.05).

Conclusions : In these ppOAG patients, vascular densities in both the macula and ONH alongside GCC, RNFL, macular thickness were all significantly reduced prior to detectable VF loss. Macular and ONH capillary loss may occur prior to visual dysfunction and serve as early biomarkers alongside structural changes to both the macula and ONH in patients with OAG.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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