June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Non-glaucomatous persons with diabetes have reduced macular capillary density potentially elevating the risk for glaucoma
Author Affiliations & Notes
  • Rebecca Kellner
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alon Harris
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Richard B Rosen
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Barbara M Wirostko
    University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States
    Qlaris Bio Inc, Dedham, Massachusetts, United States
  • Brent A Siesky
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Janet Constance Coleman-Belin
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Isaac Tessone
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Michael Chang
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Anna Fabczak-Kubicka
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Gal Antman
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Ophthalmology, Rabin Medical Center, Petah Tikva, Central, Israel
  • Footnotes
    Commercial Relationships   Rebecca Kellner None; Alon Harris AdOM, Qlaris, Luseed, Cipla , Code C (Consultant/Contractor), AdOM, Luseed, Oxymap, Qlaris, Phileas Pharma, SlitLed, QuLent , Code I (Personal Financial Interest), AdOM, Qlaris, Phileas Pharma , Code S (non-remunerative); Richard Rosen Optovue, Boehriger-Ingelheim, Code C (Consultant/Contractor), Topcon, Code F (Financial Support), Optovue, Guardion, Opticology, Code I (Personal Financial Interest), Optovue, Code P (Patent), Ocusciences, Topcon, Code R (Recipient), OD-OS, Code S (non-remunerative); Barbara Wirostko None; Brent Siesky None; Alice Chandra Verticchio Vercellin None; Janet Coleman-Belin None; Isaac Tessone None; Michael Chang None; Anna Fabczak-Kubicka None; Gal Antman None
  • Footnotes
    Support  NIH grant (R01EY030851); NSF DMS (1853222/2021192); NYEE Foundation grants; in part by a Challenge Grant award from Research to Prevent Blindness, NY; National Institutes of Health under award numbers R01EY027301 and R01HL159116; additional funding for this research was provided by the Marrus Family Foundation, Challenge Grant award from Research to Prevent Blindness, the Jorge N. Buxton Microsurgical Foundation, and the New York Eye & Ear Foundation.
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4721. doi:
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    • Get Citation

      Rebecca Kellner, Alon Harris, Richard B Rosen, Barbara M Wirostko, Brent A Siesky, Alice Chandra Verticchio Vercellin, Janet Constance Coleman-Belin, Isaac Tessone, Michael Chang, Anna Fabczak-Kubicka, Gal Antman; Non-glaucomatous persons with diabetes have reduced macular capillary density potentially elevating the risk for glaucoma. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4721.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine differences in macular and peripapillary structure and peripapillary and macular capillary densities in open angle glaucoma (OAG) patients and healthy persons with and without diabetes (DM).

Methods : Seventy-nine OAG patients (63 non-DM, 16 DM) and 113 persons free from eye disease (106 non-DM, 7 DM) were examined in a prospective, cross-sectional analysis for macular and peripapillary capillary blood vessel densities (VD) via optical coherence tomography angiography (OCTA, Optovue). Intraocular pressure (IOP), blood pressure (BP), heart rate (HR), ocular perfusion pressure (OPP), visual fields (VF), macular thickness, optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness were also assessed. Comparisons were adjusted for age, sex, race, BMI level, age, diabetes and high blood pressure / hypertension, with p<0.05 considered statistically significant.

Results : Macular VD were significantly lower in the superior outer (p=0.015), inferior outer (p=0.013), and inferior inner (p=0.04) regions in non-glaucomatous DM patients compared to those without DM. IOP was more strongly correlated to VD in the inferior inner region of the macula in OAG patients with DM compared to those without DM (r=0.85 vs 0.10; p=0.002). There were no statistically significant differences in peripapillary VD, IOP, VF, BP, OPP, ONH, RNFL, or macular structural parameters between persons with glaucoma and DM versus glaucoma without DM (p>0.05).

Conclusions : Non-glaucomatous persons with DM have reduced macular capillary VD compared to persons without diabetes. In addition, the presence of DM may alter the relationship between IOP and retinal capillary function in patients with OAG.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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