June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The retinal vascular network with Singapore "I" Vessel Assessment (SIVA) software and brain magnetic resonance imaging markers of cerebral small vessel disease in the elderly: The Montrachet study
Author Affiliations & Notes
  • Louis Arnould
    University Hospital Dijon, France
    ISPED, Bordeaux, Aquitaine, France
  • Aicha Soumare
    ISPED, Bordeaux, Aquitaine, France
  • Cécile Delcourt
    ISPED, Bordeaux, Aquitaine, France
  • Catherine Helmer
    ISPED, Bordeaux, Aquitaine, France
  • Catherine Creuzot-Garcher
    University Hospital Dijon, France
  • Stéphanie Debette
    ISPED, Bordeaux, Aquitaine, France
  • Footnotes
    Commercial Relationships   Louis Arnould None; Aicha Soumare None; Cécile Delcourt None; Catherine Helmer None; Catherine Creuzot-Garcher None; Stéphanie Debette None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4668. doi:
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      Louis Arnould, Aicha Soumare, Cécile Delcourt, Catherine Helmer, Catherine Creuzot-Garcher, Stéphanie Debette; The retinal vascular network with Singapore "I" Vessel Assessment (SIVA) software and brain magnetic resonance imaging markers of cerebral small vessel disease in the elderly: The Montrachet study. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4668.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the association between retinal vessel geometric characteristics with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (cSVD) and cSVD composite extreme phenotype.

Methods : Design: Cross-sectional study, population-based study.
Participants: Community-dwelling individuals aged 75 years without dementia and clinical stroke from the Montrachet Study
Methods: At baseline, imaging markers of cSVD were assessed with 1.5-Tesla MRI. Ten years after participants had a fundus with valid measurements of retinal parameters (arterioles and venules fractal dimension [FD], caliber and curvature tortuosity) with Singapore “I” Vessel Assessment software. Inclusion criteria were absence of brain tumor on MRI, absence of clinical diagnosis for dementia or stroke pre-MRI and absence of ophthalmic conditions interfering with macular or peripapillary retinal vasculature.
Main Outcome Measures: MRI markers of cSVD: total white matter hyperintensities volume (WMHV) and brain infarcts/lacunes of presumed vascular origin. A composite MRI-derived phenotype for extremes cSVD, based on age and gender-adjusted WMH and lacunes creating participants groups with extensive versus minimal cSVD severity.

Results : Overall, 670 participants were included in the analysis. In model adjusted for age at MRI, gender, axial length and vascular risk factors, we observed a nominally significant association between low arteriolar FD and reduced arteriolar caliber with high total WMHV (respectively, p = 0.023 and p = 0.033). Reduced arteriolar FD was significantly associated with extensive cSVD participants (n = 71) after adjustment for age at MRI, gender, axial length, and baseline vascular risk factors (p = 0.002).

Conclusions : Retinal vessel geometric characteristics (arteriolar caliber and FD) were associated with MRI markers and extensive phenotype of cSVD in elderly participants of the Montrachet population-based study

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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