June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Wide-field optical coherence tomography in retinitis pigmentosa
Author Affiliations & Notes
  • Ulrich Kellner
    Rare Retinal Disease Center, MVZ Augenärztliches Diagnostik- und Therapiecentrum Siegburg GmbH, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Heidi Stoehr
    Humangenetik Ostbayern, Regensburg, Germany
  • Christina Kiel
    Humangenetik Ostbayern, Regensburg, Germany
  • Simone Kellner
    Rare Retinal Disease Center, MVZ Augenärztliches Diagnostik- und Therapiecentrum Siegburg GmbH, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Silke Weinitz
    Rare Retinal Disease Center, MVZ Augenärztliches Diagnostik- und Therapiecentrum Siegburg GmbH, Siegburg, Germany
    RetinaScience, Bonn, Germany
  • Ghazaleh Farmand
    Rare Retinal Disease Center, MVZ Augenärztliches Diagnostik- und Therapiecentrum Siegburg GmbH, Siegburg, Germany
  • Bernhard HF Weber
    Humangenetik Ostbayern, Regensburg, Germany
  • Footnotes
    Commercial Relationships   Ulrich Kellner None; Heidi Stoehr None; Christina Kiel None; Simone Kellner None; Silke Weinitz None; Ghazaleh Farmand None; Bernhard Weber None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4655. doi:
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      Ulrich Kellner, Heidi Stoehr, Christina Kiel, Simone Kellner, Silke Weinitz, Ghazaleh Farmand, Bernhard HF Weber; Wide-field optical coherence tomography in retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4655.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the additional information provided by wide-field optical coherence tomography (W-OCT) compared to conventional macular volume scan OCT (M-OCT) in retinitis pigmentosa (RP).

Methods : A consecutive series of 260 RP patients diagnosed based on either clinical or molecular genetic findings were examined at least once between 2015 and 2022. Ophthalmologic examination included clinical examination, W-OCT, M-OCT, fundus (FAF) and near-infrared autofluorescence (NIA) in wide-field and macular mode (Spectralis, Heidelberg Engineering, Germany). W-OCT was evaluated in respect to provision of additional information compared to M-OCT. Molecular genetic analysis was performed in all patients who gave informed consent.

Results : In 126/260 patients the clinical diagnosis of RP was confirmed by molecular genetic findings. In 249/260 patients W-OCT could be evaluated in a volume scan. In 182/249 patients, the area of preserved photoreceptors (= present ellipsoid zone (EZ) layer) was completely within the field evaluated by M-OCT. Of the remaining 67 patients, the area of preserved EZ could be completely documented with W-OCT in 64/67 patients. In addition, W-OCT provided further information on mid-peripheral areas of preserved retinal layer integrity, the presence of abnormal bulbus configuration due to high myopia or posterior staphyloma. Lesions detectable on W-OCT corresponded to lesion visible in wide-field FAF and NIA.

Conclusions : W-OCT as well as wide-field FAF and NIA are suitable methods for non-invasive evaluation of retinal structure beyond the macular area in RP patients, especially in earlier stages with more preserved retinal structures towards the mid-periphery.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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