June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Mesopic microperimetry is correlated with vision-related quality of life in patients with retinitis pigmentosa
Author Affiliations & Notes
  • Jessica Serena Karuntu
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Xuan-Thanh-An Nguyen
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Camiel J.F. Boon
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
    Ophthalmology, Amsterdam UMC Locatie AMC, Amsterdam, North Holland, Netherlands
  • Footnotes
    Commercial Relationships   Jessica Karuntu None; Xuan-Thanh-An Nguyen None; Camiel Boon None
  • Footnotes
    Support  UitZicht grant
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4639. doi:
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      Jessica Serena Karuntu, Xuan-Thanh-An Nguyen, Camiel J.F. Boon; Mesopic microperimetry is correlated with vision-related quality of life in patients with retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4639.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The next step towards successful clinical trials for retinitis pigmentosa (RP) is finding sensitive objective measurements, such as microperimetry and Low Luminance Visual Acuity (LLVA), and subjective outcome measures based on patient experiences. The novel Michigan Retinal Degeneration Questionnaire (MRDQ) evaluates vision-related quality of life in patients with RP by scoring on seven domains: central vision, color vision, contrast sensitivity, photosensitivity, and peripheral vision under photopic, mesopic, and scotopic circumstances. This study investigates the association between microperimetry, LLVA, and vision-related quality of life in patients with RP using the MRDQ.

Methods : This cross-sectional study included twenty patients with clinically confirmed advanced RP. Best Corrected Visual Acuity (BCVA) and LLVA was measured with ETDRS charts and the latter was done in low luminance conditions of 3 cd/m2. Patients performed mesopic microperimetry using a 10-2 grid and completed a validated Dutch translation of the MRDQ.

Results : Out of twenty patients, 40% was female and mean BCVA was 1.0 (20/200) LogMAR (SD ± 0.60, range 0.22 – 2.90). Mean LLVA was 1.2 (20/355) LogMAR (SD ± 0.67, range 0.35 – 3.20). Overall, patients had a mean retinal sensitivity of 5.8 dB (SD ± 7.0, range 0.0 – 25.3 dB) on mesopic microperimetry. The highest Θ-scores on the MRDQ (Θ±SD), denoting more severe disability, were reported for mesopic peripheral vision (0.77± 0.19) and central vision (0.74±0.19). Lower visual acuity in low luminance appeared to correlate with higher experienced disability, however this apparent correlation did not reach statistical significance. Retinal sensitivity on microperimetry correlated significantly with MRDQ scores of central vision (r = -0.659; p=0.002), color vision (r = -0.541; p=0.014), contrast sensitivity (r = -0.578; p=0.008), scotopic function (r = -0.521; p=0.018), and photopic peripheral function (r = -0.474; p=0.035).

Conclusions : Patients with lower retinal sensitivity on mesopic microperimetry experienced more disability as assessed with the MRDQ, thus validating the need for combining objective outcome measure and patient-reported outcome measures for future clinical RP trials.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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