June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Gender differences in central serous chorioretinopathy based on new multimodal imaging classification
Author Affiliations & Notes
  • Richard Brown
    University of Pittsburgh Department of Ophthalmology, Pittsburgh, Pennsylvania, United States
  • Niroj Kumar Sahoo
    LV Prasad Eye Institute Kode Venkatadri Chowdary Campus, Vijayawada, India
  • Joshua Ong
    University of Pittsburgh Department of Ophthalmology, Pittsburgh, Pennsylvania, United States
  • Amrish Selvam
    University of Pittsburgh Department of Ophthalmology, Pittsburgh, Pennsylvania, United States
  • Milana Avdalimov
    Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Tel Aviv, Israel
  • Ashwini Kulkarni
    LV Prasad Eye Institute Kode Venkatadri Chowdary Campus, Vijayawada, India
  • Saarang Hansraj
    LV Prasad Eye Institute, Hyderabad, Telangana, India
  • Ramkailash Gujar
    Oregon Health & Science University Casey Eye Institute, Portland, Oregon, United States
    Ophthalmology, Universita degli Studi di Perugia Dipartimento di Medicina e Chirurgia, Perugia, Umbria, Italy
  • Supriya Arora
    Division of Ophthalmology, Department of Surgery, Princess Margaret Hospital, Bahamas
  • Sumit Randhir Singh
    Nilima Sinha Medical College & Hospital, Rampur, India
  • Marco Lupidi
    Ophthalmology, Universita degli Studi di Perugia Dipartimento di Medicina e Chirurgia, Perugia, Umbria, Italy
  • Dinah Zur
    Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Tel Aviv, Israel
  • Jay Chhablani
    University of Pittsburgh Department of Ophthalmology, Pittsburgh, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Richard Brown None; Niroj Sahoo None; Joshua Ong None; Amrish Selvam None; Milana Avdalimov None; Ashwini Kulkarni None; Saarang Hansraj None; Ramkailash Gujar None; Supriya Arora None; Sumit Singh None; Marco Lupidi None; Dinah Zur None; Jay Chhablani None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4626. doi:
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      Richard Brown, Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Milana Avdalimov, Ashwini Kulkarni, Saarang Hansraj, Ramkailash Gujar, Supriya Arora, Sumit Randhir Singh, Marco Lupidi, Dinah Zur, Jay Chhablani; Gender differences in central serous chorioretinopathy based on new multimodal imaging classification. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4626.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A novel, reproducible, multimodal imaging classification system has recently been proposed to categorize cases of central serous chorioretinopathy (CSCR). We conducted a multicentric, retrospective, longitudinal, observational study to analyze the gender-specific differences in CSCR based on this new classification system.

Methods : The study included 109 eyes of 58 patients (55 eyes of 28 female patients and 54 eyes of 30 male patients). Adult patients with a diagnosis of unilateral or bilateral CSCR and at least three years of follow-up were included. Visual acuity outcomes, differences based on ‘Simple’ and ‘Complex’ CSCR, occurrence of choroidal neovascularization (CNV), number of recurrences, and need for retreatment were analyzed. Comparison of baseline and final values were performed using Wilcoxon signed rank test. Factors affecting the final visual acuity and need for treatment were analyzed using linear and logistic regression, respectively. A p-value of <0.05 was selected as statistically significant.

Results : The mean age of the male and female groups was similar (47.3±10.3 years in males and 40.3±10.2 years in females; p=0.13). Simple CSCR was seen in 8 (14.8%) eyes and 21 (38.2%) eyes in male and female group, respectively, while Complex CSCR was seen in 46 (85.2%) eyes and 34 (61.8%) eyes in male and female groups, respectively (p=0.003). Recurrence was significantly more commonly in males (34 eyes) than in females (23 eyes) (p=0.03). Males were also significantly more likely to have a bilateral presentation (p=0.03). CNV was seen in 8 female eyes compared to 4 male eyes (4 eyes) (p=0.23). On multivariable regression analysis, factors affecting reduced need for treatment were history of steroid use, good visual acuity at baseline, and Simple CSCR. Factors affecting good final visual acuity were history of steroid use, good visual acuity at baseline, and younger age. Gender did not influence the need for treatment and final visual acuity.

Conclusions : Males tended to exhibit Complex CSCR, recurrence, and bilaterality compared to the female sub-group. Females developed CNV more frequently than males.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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