June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Interocular Symmetry of Retinal Nerve Fiber Layer and Optic Nerve Head Parameters Using Optical Coherence Tomography in a Ghanaian Population.
Author Affiliations & Notes
  • Clement Afari
    Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana
  • Kwadwo Antwi Appiagyei
    Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana
  • Thelma Appiah-Warden
    Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana
  • Footnotes
    Commercial Relationships   Clement Afari None; Kwadwo Antwi Appiagyei None; Thelma Appiah-Warden None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, OD92. doi:
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      Clement Afari, Kwadwo Antwi Appiagyei, Thelma Appiah-Warden; Interocular Symmetry of Retinal Nerve Fiber Layer and Optic Nerve Head Parameters Using Optical Coherence Tomography in a Ghanaian Population.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):OD92.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Ghana is reported to have the second leading prevalence of glaucoma worldwide, but there is a paucity of normative data on the interocular symmetry of optical coherence tomography (OCT) results. This study is to determine the normal interocular symmetry in the retinal nerve fibre layer (RNFL) and optic nerve head (ONH) parameters from OCT results in the Ghanaian population.

Methods : The study was a retrospective clinical-based population study that retrieved and analyzed adult patients' ocular health records, including OCT and visual field test (VFT) results. Only 210 records of patients without any ophthalmic conditions except for refractive errors who visited multi-center eye clinics in Ghana from January 2021 to March 2022 were analyzed. OCT scans were obtained from these patients using the Optic Disc Cube 200 x 200 protocol using the Cirrus HD-OCT. The interocular differences in RNFL thickness were calculated as right eyes minus left eyes. Measurements of the two eyes were compared using a paired T-test. The normal ranges of interocular differences were determined as the 2.5th and 97.5th percentiles. For all analyses, a p-value <0.05 was considered statistically significant.

Results : The average RNFL in the right eye was 1.039 ± 4.671 μm thicker than in the left (p <0.001). The Optic Nerve Head (ONH) parameters (rim area, cup volume, average cup-to-disc ratio and Vertical CDR) showed no statistically significant interocular difference except for the disc area, which was -0.034 ± 0.277 (P<0.009). The 2.5th and 97.5th percentiles interocular difference tolerance limit for the average RNFL thickness was -7.57 μm and 10.00 μm, respectively. The vertical CDR interocular difference is not influenced by increasing age.

Conclusions : There exists a normal variation in the average interocular RNFL thickness. Our results contribute to the standard reference of the degree of interocular symmetry of RNFL and Optic nerve head OCT parameters in the Ghanaian population.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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