June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Comparison of Modal and Zonal Wavefront Measurements of Refractive Extended Depth of Focus Intraocular Lenses
Author Affiliations & Notes
  • Geunyoung Yoon
    College of Optometry, University of Houston, Houston, Texas, United States
  • Seungpil Bang
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, United States
  • Hae Won Jung
    College of Optometry, University of Houston, Houston, Texas, United States
  • Myoung Joon Kim
    Renew Seoul Eye Center, Korea (the Republic of)
  • Jong Hwa Jun
    Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Daegu, Korea (the Republic of)
  • Seth Pantanelli
    Department of Ophthalmology, The Pennsylvania State University, Hershey, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Geunyoung Yoon None; Seungpil Bang None; Hae Won Jung None; Myoung Joon Kim None; Jong Hwa Jun None; Seth Pantanelli Bausch & Lomb, Code C (Consultant/Contractor), Carl Zeiss Meditec, Code C (Consultant/Contractor), Alcon, Code F (Financial Support), Bausch & Lomb, Code F (Financial Support), Carl Zeiss Meditec, Code F (Financial Support), Ocular Therapeutix, Code F (Financial Support)
  • Footnotes
    Support  NIH Grant EY 014999; Asan Foundation Scholarship; GC Pharma Scholarship
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5425. doi:
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      Geunyoung Yoon, Seungpil Bang, Hae Won Jung, Myoung Joon Kim, Jong Hwa Jun, Seth Pantanelli; Comparison of Modal and Zonal Wavefront Measurements of Refractive Extended Depth of Focus Intraocular Lenses. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5425.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical performance of extended depth of focus (EDoF) intraocular lenses (IOLs) is commonly evaluated by measuring Zernike spherical aberrations (SA) with a commercially available aberrometer. The goal of the study is to assess errors induced by the wavefront estimated by a limited number of SAs.

Methods : An ultrahigh resolution Shack-Hartmann wavefront sensor was developed by using a small lenslet array (133 µm) and a large CCD sensor (24 by 36 mm). The pupil was magnified by a factor of 5, resulting in 26.6 µm sampling resolution. Four refractive EDoF IOLs with 20D (Vivity, Alcon Laboratories, Inc; Tecnis Eyhance, Johnson & Johnson Vision; Isopure, PhysIOL; and Lucidis, Swiss Advanced Vision) in a wet chamber filled with the balanced salt solution were measured with zonal and Zernike-based modal wavefront reconstruction methods. The modal method calculated Zernike coefficients up to the 18th order while the zonal method reconstructed the local wavefront for each lenslet. The reconstructed wavefronts were analyzed for 2, 3, and 4 mm diameters.

Results : All IOLs had negative 4th-order SA for 4 mm diameter, and Isopure and Lucidis had the largest (-0.34 µm) and smallest (-0.07 µm) magnitude, respectively. The magnitude was reduced significantly for the smaller diameters except that Lucidis had a slight increase (-0.12 µm). All IOLs had 6th- and 8th-order SAs, and Vivity and Lucidis also showed the 10th-order SA. The wavefront difference between the zonal (up to the 6th order) and modal methods represented by the mean squared error (MSE) was larger in Vivity and Lucidis, compared to Eyhance and Isopure. However, further increasing the Zernike fit up to the 10th order reduced the MSE significantly for Vivity and Lucidis while the negligibly small MSE for Eyhance and Isopure remained unchanged. With even up to the 18th-order polynomials for Vivity and Lucidis, the MSE remained significant.

Conclusions : The study suggested that the recent refractive EDoF IOLs have a complicated optical profile that cannot be characterized sufficiently by a relatively small number of Zernike SAs. Therefore, using a commercial aberrometer to investigate the optics of the specialty IOLs could misinterpret the true design performance.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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