June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Risk factors for developing subretinal fluid in the fellow eye in chronic central serous chorioretinopathy patients
Helena Margaret Anthonia Feenstra; Tahir Çakar; Camiel J F Boon; Elon Van Dijk
Author Affiliations & Notes
  • Helena Margaret Anthonia Feenstra
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Tahir Çakar
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Camiel J F Boon
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
    Ophthalmology, Amsterdam UMC Locatie AMC, Amsterdam, North Holland, Netherlands
  • Elon Van Dijk
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Footnotes
    Commercial Relationships   Helena Feenstra None; Tahir Çakar None; Camiel Boon None; Elon Van Dijk None
  • Footnotes
    Support  H.M.A. Feenstra was supported by the Blindenhulp Fellowship from Stichting Blindenhulp (The Hague, the Netherlands).This research was also supported by the following foundations: Stichting Ooglijders (Rotterdam, the Netherlands); Stichting Macula Fonds; Retina Nederland Onderzoek Fonds; Stichting Blinden-Penning; Algemene Nederlandse Vereniging ter Voorkoming van Blindheid; Landelijke Stichting voor Blinden en Slechtzienden, which contributed through UitZicht (Delft, the Netherlands); Rotterdamse Stichting Blindenbelangen (Rotterdam, the Netherlands); Stichting Leids Oogheelkundig Ondersteuningsfonds (Leiden, the Netherlands); the Oxford NIHR Biomedical Research Center (Oxford, United Kingdom); the Gisela Thier Fellowship of Leiden University (Leiden, the Netherlands (C.J.F.B.)); and the Netherlands Organization for Scientific Research (VENI grant to C.J.F.B.). These funding organizations provided unrestricted grants and had no role in the design or conduct of this research.
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5405. doi:
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      Helena Margaret Anthonia Feenstra, Tahir Çakar, Camiel J F Boon, Elon Van Dijk; Risk factors for developing subretinal fluid in the fellow eye in chronic central serous chorioretinopathy patients. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5405.

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Abstract

Purpose : There is a lack of knowledge in terms of predicting of the risk of subretinal fluid (SRF) development in the fellow eye of chronic central serous chorioretinopathy (cCSC) patients with unilateral SRF at baseline. We performed a retrospective, clinical study to determine the risk factors for development of SRF in fellow eyes of such cCSC patients.

Methods : The files and multimodal imaging of 334 presumed cCSC patients from Leiden University Medical Center were retrospectively analyzed for inclusion in this study. Multimodal imaging consisted of optical coherence tomography (OCT) scans, fluorescein angiography (FA), indocyanine-green angiography (ICGA), and fundus autofluorescence. Inclusion criteria for this study included: findings typical of cCSC on FA and ICGA, unilateral subretinal fluid on OCT at first visit to the clinic (baseline visit), follow-up of at least 3 months, absence of other ocular diseases that may cause SRF. During follow-up, all available OCT scans of the fellow eye were screened for SRF development. In addition, at baseline visit the presence of retinal pigment epithelial (RPE) alterations on OCT (RPE detachment, RPE attenuation, RPE bumps) or RPE window defects on FA was documented and compared between the patients who did and did not develop SRF during follow-up, by using a Fisher’s exact test.

Results : A diagnosis of cCSC was confirmed on FA and ICGA in 233 patients, out of whom 72 (32%) had bilateral SRF on OCT at baseline. A total of 102 patients had unilateral SRF at baseline and met the other inclusion criteria. The mean follow-up was 21 months. During follow up, 7/102 (6.7%) cCSC patients developed SRF in fellow eye after a mean period of 17 months. RPE alterations in the fellow eye at baseline were present in 5/7 (71.4%) in the SRF group versus 29/93 (31.2%) in the group who did not develop SRF in the fellow eye (p=0.043). Age, gender, and ethnicity were not associated with the development of SRF in fellow eye during follow-up.

Conclusions : The presence of RPE alterations in the fellow eye at baseline may be a predicting risk factor for the development of SRF in the fellow eye of patients with unilateral cCSC.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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