Abstract
Purpose :
Acute zonal occult outer retinopathy (AZOOR) is characterized by the sudden onset of subjective scotomas and photopsia due to the outer retinal damage with a normal fundus aspect. Therefore, especially optical coherence tomography and ERGs are essential examinations for correct diagnosis. Although there have been reports of ERG characteristics in AZOOR patients, few reports have examined the relationship between ERG and visual acuity. Here, we examined the correlation between the electroretinogram (ERG) and visual acuity prognosis.
Methods :
Retrospectively, AZOOR patients who were performed ERGs including full-field ERG in Juntendo University Hospital from First, April, 2015 to 30th, June, 2022, were recruited in this study. The diagnosis of AZOOR was followed guideline (Nichigankaishi, 2019). ERGs were performed according to ISCEV standard protocol. The initial full-field ERG was classified into normal, moderately affected, and severe affected response (including non-recordable) of the rod and cone responses, respectively. ERGs severity classification was done by two ophthalmologists (T.H. and F.H.). The latest logarithm of the minimum angle of resolution best corrected visual acuity (LogMAR BCVA) during follow-up was used. Then, the final LogMAR BCVA for each group classified by initial ERG severity was compared by statistical analysis with One-way ANOVA and Tukey’s multiple-comparison test.
Results :
31 cases (5 male and 26 female) and 51 eyes were recruited in this study. The mean LogMAR BCVA was (0.23), (0.35), and (0.70); (0.17), (0.26), and (0.60); normal, moderate, and severe affected rod and cone of full-field ERG responses, respectively. In one-way ANOVA analysis, the severity of both cone (p=0.01) and rod (p=0.02) responses of the full-field ERG were associated with final visual outcome. In the full-field ERG, final LogMAR BCVA in the normal response group was significantly worse than in the severe affected response group in both dark- (p=0.015) and light-adapted (p=0.01) conditions, respectively.
Conclusions :
These data suggest that ERGs are predictive of visual prognosis in AZOOR patients. AZOOR patients with particularly severe ERG reactions may have a poor visual prognosis and may benefit from early therapeutic intervention; further study is needed.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.