June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Sensitivity and dry eye symptoms on patients with type 1 Diabetes Mellitus.
Author Affiliations & Notes
  • Ana Paulina Murillo López
    Cornea, external diseases and refractive surgery, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico City, Mexico
  • David Jimenez-Collado
    Cornea, external diseases and refractive surgery, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico City, Mexico
  • Alejandro Navas
    Cornea, external diseases and refractive surgery, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico City, Mexico
  • Jalil Sánchez Naranjo
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
  • David Rivera de la parra
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
  • Enrique O Graue-Hernandez
    Cornea, external diseases and refractive surgery, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico City, Mexico
  • Footnotes
    Commercial Relationships   Ana Murillo López None; David Jimenez-Collado None; Alejandro Navas None; Jalil Sánchez Naranjo None; David Rivera de la parra None; Enrique Graue-Hernandez None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5153. doi:
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      Ana Paulina Murillo López, David Jimenez-Collado, Alejandro Navas, Jalil Sánchez Naranjo, David Rivera de la parra, Enrique O Graue-Hernandez; Sensitivity and dry eye symptoms on patients with type 1 Diabetes Mellitus.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5153.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In patients with type 1 diabetes mellitus (T1DM), there are related metabolic changes at first, in smaller caliber nerve fibers such as A delta and C, which are unmyelinated and are known as thin fibers. These fibers are found in the cornea and are responsible for the perception of fine touch, pain and temperature. In this studio, it was studied show if there is a difference in sensitivity and dry eye symptoms, between healthy patients and T1DM.

Methods : A population of 105 patients with T1DM was taken, over 18. Who have their metabolic control on Salvador Zubirán National Institute of medical Sciences and Nutrition. Patients taking neuromodulatory drugs, with diagnosis of VIH or major depression were excluded. At the ophthalmology institute “Conde de Valenciana”, these patients were studied, an esthesiometry was performed them in both eyes, taking the 4 peripheral quadrants (superior, temporal, inferior and nasal quadrant) and the central one of the cornea. Taking as hypesthesia form 5.5 mm. Also, a questionnaire was applied in these patients; DEQ-5, to classify dry eye symptoms in them. Qualifying as severe 12-13, moderate 11, mild 5-10 and without pathology 0-5.

Results : The average of each eye was obtained, in patients with T1DM, what was obtained 9 with corneal hypoesthesia in both eyes (8.57%), 5 in right eye (4.76%), 7 in left eye only (6.66%) y 84 without hypoesthesia (80%) and the mean of their esthesiometry were 5.62. Healthy patients 100% did not have any type of hypoesthesia and the mean of their esthesiometry were 5.95. In the DEQ-5, the result in patients with type 1 diabetes mellitus were; 50 without pathology (47.61%), 39 mild (37.14%), 2 moderate (1.90%) and 14 severe (13.33%). The result in the healthy patients were 14 without pathology (70%), 2 mild (10%), 0 moderate (0%) and 4 severe (20%).

Conclusions : Dry eye symptoms were present on 52.37% of patients with T1DM, most common mild dry eye symptoms were present and around 20% with corneal hypoesthesia in at least one eye. In conclusion, some mild dry eye symptoms could be present in well controlled T1DM, also they could have some corneal hypoesthesia.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

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