June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The relationship between blood flow velocity and local nonperfusion area in healthy and diabetic retinopathy eyes
Author Affiliations & Notes
  • Hisashi Fukuyama
    Ophthlmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
    Ophthlmology, Hyogo Ika Daigaku, Nishinomiya, Hyogo, Japan
  • Jessica Moonjely
    Ophthlmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Daniela Castellanos -Canales
    Ophthlmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Nicole Louise Louise Decker
    Ophthlmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Amani A Fawzi
    Ophthlmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Hisashi Fukuyama None; Jessica Moonjely None; Daniela Castellanos -Canales None; Nicole Louise Decker None; Amani Fawzi Regeneron, Code C (Consultant/Contractor), Roche/Genentech, Code C (Consultant/Contractor), Boehringer Ingelheim, Code C (Consultant/Contractor), RegenXbio, Code C (Consultant/Contractor), 3Helix, Code C (Consultant/Contractor), Boehringer Ingelheim, Code F (Financial Support)
  • Footnotes
    Support  NIH grant R01EY31815
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 550. doi:
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      Hisashi Fukuyama, Jessica Moonjely, Daniela Castellanos -Canales, Nicole Louise Louise Decker, Amani A Fawzi; The relationship between blood flow velocity and local nonperfusion area in healthy and diabetic retinopathy eyes. Invest. Ophthalmol. Vis. Sci. 2023;64(8):550.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the relationship between perivascular nonperfusion area on OCT angiography (OCTA) and blood velocity on adaptive optics (AOSLO) in healthy and diabetic subjects

Methods : This is a prospective study including healthy subjects with no diabetes mellitus (DM), subjects with DM but without diabetic retinopathy (noDR), and subjects with (nonproliferative DR (NPDR) and proliferative DR (PDR)). We analyzed AOSLO-based retinal blood velocity using semi-automated measurements of erythrocyte streak angles on AOSLO images. We used geometric perfusion deficit (GPD) analysis in OCTA to evaluate the local nonperfusion area around the same vessel, defined as the retinal area located further than 30 μm from the nearest blood vessel. We analyzed the percent area of GPD in the 100 μm perimeter around the vessels (Fig 1). We evaluated the correlation between retinal blood velocity and perivascular GPD.

Results : We included 9 arteries in 8 eyes of healthy subjects and 18 arteries in 12 eyes with noDR and 15 arteries in 11 eyes with clinical DR (9 eyes; NPDR, 2 eyes; PDR). As shown in figure 2, in the healthy subjects, blood velocity was significantly positively correlated with periarterial GPD in the superficial plexus (SCP) (ρ = 0.773, P=0.025). On the other hand, blood velocity was significantly negatively correlated with periarterial GPD in the deep plexus (DCP) in eyes with noDR (ρ = -0.507, P = 0.032). We found no significant correlations in SCP (P=0.91) or DCP (P=0.67) in eyes with clinical DR.

Conclusions : This study suggests that in healthy eyes, blood velocity is increased to meet the demand of the hypoxic retina. In preclinical DR eyes, failure of these autoregulatory mechanisms primarily impacts the DCP and may contribute to further capillary drop-out in DCP.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. Left eye of a 23-year-old healthy subject.
(Top left) Averaged OCTA of five scans of superficial plexus. (Top right) Blue arrow on the OCTA image localizes the region of XT imaged with AOSLO. Blood velocity of an artery was measured using XT image. (Bottom) GPD in OCTA and region surrounded by yellow line localized GDP of periarteriolar space.

Figure 1. Left eye of a 23-year-old healthy subject.
(Top left) Averaged OCTA of five scans of superficial plexus. (Top right) Blue arrow on the OCTA image localizes the region of XT imaged with AOSLO. Blood velocity of an artery was measured using XT image. (Bottom) GPD in OCTA and region surrounded by yellow line localized GDP of periarteriolar space.

 

Figure 2. Correlation between blood velocity and GPD in Healthy, noDR, and clinical DR eyes.

Figure 2. Correlation between blood velocity and GPD in Healthy, noDR, and clinical DR eyes.

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