June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Topographic Assessment of Intraretinal Cystic Lesions and Its Prognostic Values in Idiopathic Epiretinal Membrane
Author Affiliations & Notes
  • Iksoo Byon
    Pusan National University School of Medicine, Busan, Korea (the Republic of)
    Pusan National University Hospital, Busan, Korea (the Republic of)
  • Han Jo Kwon
    Pusan National University Hospital, Busan, Korea (the Republic of)
  • Eun Ah Kim
    Pusan National University Hospital, Busan, Korea (the Republic of)
  • Bo Hyun Park
    Pusan National University Hospital, Busan, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Iksoo Byon Bayer, Novartis , Samsung Bioepis, Roche, Code C (Consultant/Contractor), Bayer, Novartis, Code F (Financial Support), Alcon, Bayer, Hanmi, Hanlim, Novartis, Roche, Samil, Taejun, Code R (Recipient); Han Jo Kwon None; Eun Ah Kim None; Bo Hyun Park None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3660. doi:
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      Iksoo Byon, Han Jo Kwon, Eun Ah Kim, Bo Hyun Park; Topographic Assessment of Intraretinal Cystic Lesions and Its Prognostic Values in Idiopathic Epiretinal Membrane. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3660.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the topographic distribution of intraretinal cystic lesion (IRC) and its prognostic value in idiopathic epiretinal membrane (iERM).

Methods : One hundred and twenty-two iERM eyes that were followed up at least 6 months after surgery were retrospectively reviewed. All eyes were imaged by a swept-source optical coherence tomography (OCT) and fluorescein angiography. IRC was defined as a hypo-reflective space of 32 μm diameter or greater in the cross-sectional OCT images. Based on the IRC distribution, eyes were divided into groups A, B, and C (absence, existence of IRC within 3 mm, and 6 mm from the fovea, respectively). The best-corrected visual acuity (BCVA), central subfield macular thickness (CSMT), ectopic inner foveal layer (EIFL), and microvascular leakage (ML) were assessed.

Results : Of total, 56 (45.9%) eyes showed IRC. Thirty-five eyes (28.7%) were in group B and 21 (17.2%) in group C at baseline. Compared to group B, group C showed worse BCVA, thicker CSMT, and greater association with ML (OR = 5.415; p = 0.005) at baseline, and also presented worse BCVA, thicker CSMT, wider distribution of IRC, postoperatively. Sixty-one eyes (50.0%) reached good visual acuity (20/25 or better) after surgery. Among baseline factors, that older age (OR = 1.085, CI = 1.016-1.160, p = 0.015), worse BCVA (OR = 58.74, CI = 5.840-590.9, p = 0.001), and the presence of ML (OR = 3.750, CI = 1.539-9.137, p = 0.004) were unfavorable baseline factors for good visual outcome.

Conclusions : Wide distribution of IRCs was associated with more advanced disease phenotype as poor BCVA, thick macula, and existence of ML in iERM. Eyes with this featured also showed a poor visual outcome after ERM removal.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure. Classification into each group according to the distribution of intraretinal cystic lesions on en face retinal thickness maps at baseline. left column: Group A, middle column: Group B, and right column: Group C. (A) An intraretinal cyst (IRC) was absent in Group A in the 6 × 6 mm scan area. (B) Group B showed IRCs in the middle ETDRS ring within a 3 mm diameter centered on the fovea. (C) Group C was defined if any IRCs were detected over the middle ETDRS ring and spread to the 6mm from the fovea. (D~L) The scan location for each horizontal cross-sectional OCT was marked as a red dotted line on the retinal thickness map in the uppermost row.

Figure. Classification into each group according to the distribution of intraretinal cystic lesions on en face retinal thickness maps at baseline. left column: Group A, middle column: Group B, and right column: Group C. (A) An intraretinal cyst (IRC) was absent in Group A in the 6 × 6 mm scan area. (B) Group B showed IRCs in the middle ETDRS ring within a 3 mm diameter centered on the fovea. (C) Group C was defined if any IRCs were detected over the middle ETDRS ring and spread to the 6mm from the fovea. (D~L) The scan location for each horizontal cross-sectional OCT was marked as a red dotted line on the retinal thickness map in the uppermost row.

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