June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
OCTA in iris and sclera with anterior segment add-on lens and tracking
Author Affiliations & Notes
  • Zahra Nafar
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Thomas Callan
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Homayoun Bagherinia
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Andrew Chen
    Ophthalmology, University of Washington School of Medicine, Seattle, Washington, United States
  • Karine Duarte Bojikian
    Ophthalmology, University of Washington School of Medicine, Seattle, Washington, United States
  • Philip P Chen
    Ophthalmology, University of Washington School of Medicine, Seattle, Washington, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Xiao Zhou
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Zahra Nafar Carl Zeiss Meditec, Code E (Employment); Thomas Callan Carl Zeiss Meditec, Code E (Employment); Homayoun Bagherinia Carl Zeiss Meditec, Code E (Employment); Andrew Chen None; Karine Duarte Bojikian None; Philip Chen None; Ruikang Wang Carl Zeiss Meditec, Inc. , Code C (Consultant/Contractor), Carl Zeiss Meditec, Inc., Colgate Palmolive Company, Estee Lauder Inc , Code F (Financial Support), US8,750,586, US8,180,134, US9,282,905, US9,759,544, US 10,354,378, US10,529,061, Code P (Patent); Xiao Zhou None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3386. doi:
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      Zahra Nafar, Thomas Callan, Homayoun Bagherinia, Andrew Chen, Karine Duarte Bojikian, Philip P Chen, Ruikang K Wang, Xiao Zhou; OCTA in iris and sclera with anterior segment add-on lens and tracking. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3386.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCTA) of the anterior segment (AS) can provide visualization of the iris and sclera vasculature. We investigate how AS imaging can be utilized as a diagnostic tool for anterior segment degenerative ocular diseases such as pterygium, inflammatory diseases such as scleritis and proliferative retinal diseases leading to neovascularization of the iris.

Methods : An AS add-on lens was designed as an attachemnet to PLEX® Elite 9000 (ZEISS, Dublin, CA) swept-source OCT system (1060 nm central wavelength). PLEX Elite prototype software was modified and equipped with AS tracking and AS-specific scan patterns: AS Angio 18x12 mm and AS Angio 6x6 mm at 200kHz with 6 mm depth.
10 eyes in the age range of 65–80 years old, including normal, pterygium, and glaucoma were imaged with the above scan patterns. En face projection of angiographic scans were evaluated by an expert grader for quality and graded on the scale of 1-5. Grades higher than 3 were considered clinically useful based on these definitions: 1 = Unusable; 2 = Poor quality, but able to see some information; 3 = Fair. Image quality affects ability to assess/diagnose; 4 = Good. Artifacts, if any, do not interfere with assessment/diagnosis; 5 = Excellent.

Results : All 20 images were graded higher than 3 and were considered clinically useful. Figure 1 demonstrates a wide angle (18x12 mm) and a high-definition (6x6 mm) OCTA en face with minimum motion artifacts. The vessel architecture of a pterygium is visible on the wide field of view and in greater detail with the high-definition scan (b.1-2). Structural and flow projection on cross-sectional B-scans in Figure 2 highlight areas of increased vessel tortuosity (a.3), increased vascularity (b.3), and decreased vascularity (c.3).

Conclusions : AS OCTA imaging with the add-on lens attachment to a PLEX Elite instrument equipped with AS tracking, provides quality images of AS vasculature and is a promising diagnostic tool. Results show the capability of OCT/OCTA images in visualizing hypervascularity, pterygium, anterior atrophy, and structural abnormalities.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1: OCTA en face projection of a AS Angio 12x18mm (a.1, b.1, c.1) and 6x6mm (a.2, b.2,c.2) from a) Healthy, b) Pterygium, and c) Glaucoma.

Figure 1: OCTA en face projection of a AS Angio 12x18mm (a.1, b.1, c.1) and 6x6mm (a.2, b.2,c.2) from a) Healthy, b) Pterygium, and c) Glaucoma.

 

Figure 2: OCTA en face (a.1, b.1, c.1), OCT en face (a.2, b.2, c.2), and cross sectional Bscans(a.3,b.3, c.3) of AS Angio 6x6mm from a) Normal tension glaucoma, b) Pterygium, c) Open angle glaucoma

Figure 2: OCTA en face (a.1, b.1, c.1), OCT en face (a.2, b.2, c.2), and cross sectional Bscans(a.3,b.3, c.3) of AS Angio 6x6mm from a) Normal tension glaucoma, b) Pterygium, c) Open angle glaucoma

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