June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Rate and associations of inner retinal thinning in eyes with retinal vein occlusion and regressed macular edema
Author Affiliations & Notes
  • Maria Vittoria Cicinelli
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Lamberto La Franca
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Alessandro Berni
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Leonardo Bottazzi
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Alessandro Rabiolo
    Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy
  • Rosangela Lattanzio
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Francesco Bandello
    Ophthalmology, IRCCS Ospedale San Raffaele, Milano, Lombardia, Italy
  • Footnotes
    Commercial Relationships   Maria Vittoria Cicinelli None; Lamberto La Franca None; Alessandro Berni None; Leonardo Bottazzi None; Alessandro Rabiolo None; Rosangela Lattanzio None; Francesco Bandello None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3232. doi:
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      Maria Vittoria Cicinelli, Lamberto La Franca, Alessandro Berni, Leonardo Bottazzi, Alessandro Rabiolo, Rosangela Lattanzio, Francesco Bandello; Rate and associations of inner retinal thinning in eyes with retinal vein occlusion and regressed macular edema. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3232.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the associations between visual acuity (VA) and structural optical coherence tomography (OCT) features in retinal vein occlusion (RVO) eyes after cystoid macular edema (CME) regression and to assess whether inner retinal thinning is progressive.

Methods : Retrospective observational study of RVO eyes with regressed CME for at least 6 months. OCT scans at CME regression were analyzed, and features were correlated with VA at that visit. The inner retinal thickness was longitudinally compared between RVO and unaffected retinal quadrants (controls) with linear mixed models. The rate of inner retinal thinning was obtained as the interaction term between disease status and time. Associations between inner retinal thinning and clinical characteristics were explored.

Results : Thirty-six RVO eyes were followed for 34.2±21.1 months after CME regression. The presence of ellipsoid zone disruption (regression estimate[standard error(SE)]= 0.16[0.04] vs. intact, p<0.001) and lower inner retinal thickness (regression estimate[SE]= -0.25[0.12] LogMAR for 100-mm increase, p=0.01) were associated with worse VA. The inner retinal thickness decreased at a faster rate in RVO than controls (median rate of retinal thinning -0.09 [interquartile range(IQR) -0.13 to -0.04] mm/month vs. -0.07 [IQR -0.08 to -0.04] mm/month, p=0.01). Macular ischemia was associated with a faster rate of retinal thinning (interaction term macular ischemia*follow-up time, p=0.04).

Conclusions : Inner retinal and photoreceptors’ layers integrity are associated with better visual acuity once CME resolves. RVO eyes undergo progressive inner retinal thinning, presumably due to residual intracellular swelling or neurodegeneration. Macular ischemia is associated with a faster rate of inner retinal loss.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

A-F: Clinical example of inner retinal thinning at cystoid macular edema regression in an eye with branch retinal vein occlusion (RVO).

G: Boxplots comparing the rate of inner retinal thinning between RVO and fellow eyes. The mean rate was more negative (faster) in RVO eyes.

H: Scatterplot showing the inner retinal thickness values recorded over follow-up according to the presence of macular ischemia.

A-F: Clinical example of inner retinal thinning at cystoid macular edema regression in an eye with branch retinal vein occlusion (RVO).

G: Boxplots comparing the rate of inner retinal thinning between RVO and fellow eyes. The mean rate was more negative (faster) in RVO eyes.

H: Scatterplot showing the inner retinal thickness values recorded over follow-up according to the presence of macular ischemia.

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