June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Retinal oxygen saturation and retinal vascular resistance before and after treatment for central retinal vein occlusion (CRVO)
Author Affiliations & Notes
  • Yuki Nakano
    Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka, Kita-gun, Kagawa, Japan
  • yukiko myoshi
    Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka, Kita-gun, Kagawa, Japan
  • Yuta Koyama
    Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka, Kita-gun, Kagawa, Japan
  • rie osaka
    Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka, Kita-gun, Kagawa, Japan
  • Kiyoshi Suzuma
    Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka, Kita-gun, Kagawa, Japan
  • Footnotes
    Commercial Relationships   Yuki Nakano None; yukiko myoshi None; Yuta Koyama None; rie osaka None; Kiyoshi Suzuma None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1774. doi:
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      Yuki Nakano, yukiko myoshi, Yuta Koyama, rie osaka, Kiyoshi Suzuma; Retinal oxygen saturation and retinal vascular resistance before and after treatment for central retinal vein occlusion (CRVO). Invest. Ophthalmol. Vis. Sci. 2023;64(8):1774.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To invest the changes in retinal circulatory dynamics in patients with non-ischemic CRVO treated with Aflibercept vitreous injection (IVA) using retinal oximetry and laser speckle flowgraphy (LSFG).

Methods : 17 eyes in 17 patients with untreated nonischemic CRVO who underwent IVA. Retinal blood flow and retinal vascular resistance were measured with LSFG and retinal oxygen saturation were measured with Oxymap T1 at before treatment, 1, 3, 6, 9, and 12 months after treatment.

Results : Mean retinal venous oxygen saturation (V-SO2) was 37.8±10.9%, 43.9±11.0%, 46.3±11.2%, 44.2±11.7%, 46.6±11.9% and 49.0±9.8% at before treatment, 1, 3, 6, 9 and 12 months after treatment.
With LSFG, mean blur rate (MBR) was 22.2±8.1, 22.3±8.0, 22.7±10.1, 24.2±11.2, 22.2±9.8, 21.7±11.0, TCR was 1.11±0.52, 0.84±0.38, 0.92±0.54, 1.07±0.57, 0.99±0.53, 1.22±0.60 in the CRVO eyes.
V-SO2 decreased and total capillary resistance (TCR) increased in CRVO eyes, and V-SO2 increased and TCR decreased after IVA treatment, showing a negative correlation between V-SO2 and TCR at 6, 9 and 12 months.

Conclusions : In CRVO, increased vascular resistance causes stasis of retinal blood flow, which in turn increases oxygen diffusion and increases V-SO2. It can be inferred that treatment decreases vascular resistance, thereby decreasing oxygen diffusion and V-SO2.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Title: Retinal oxygen saturation with Oxymap T1
Upper solid line: oxygen saturation of artery
Lower brake line: oxygen saturation of vein
*p<0.05, **p<0.01 ANOVA

Title: Retinal oxygen saturation with Oxymap T1
Upper solid line: oxygen saturation of artery
Lower brake line: oxygen saturation of vein
*p<0.05, **p<0.01 ANOVA

 

Title: Total capillary resistance (TCR) with LSFG
Upper solid line: TCR in CRVO eyes
Lower brake line: TCR in fellow eyes
No significant difference.

Title: Total capillary resistance (TCR) with LSFG
Upper solid line: TCR in CRVO eyes
Lower brake line: TCR in fellow eyes
No significant difference.

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