June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia
Author Affiliations & Notes
  • Hongli Yang
    Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Discoveries in Sight Research Laboratories, Legacy Devers Eye Institute at Legacy Good Samaritan Medical Center, Portland, Oregon, United States
  • Ya Xing Wang
    Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing, Beijing, China
  • JInwook Jeoung
    Department of Ophthalmology, Seoul National University Hospital, Seoul, Seoul, Korea (the Republic of)
  • Seungwoo Hong
    Yebon Eye Clinic, Seoul, Korea (the Republic of)
  • Stuart Keith Gardiner
    Discoveries in Sight Research Laboratories, Legacy Devers Eye Institute at Legacy Good Samaritan Medical Center, Portland, Oregon, United States
  • Juan Reynaud
    Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Discoveries in Sight Research Laboratories, Legacy Devers Eye Institute at Legacy Good Samaritan Medical Center, Portland, Oregon, United States
  • Brad Fortune
    Discoveries in Sight Research Laboratories, Legacy Devers Eye Institute at Legacy Good Samaritan Medical Center, Portland, Oregon, United States
  • Michael J A Girard
    Biomedical Engineering, National University of Singapore, Singapore, Singapore
  • Glen Sharpe
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Marcelo Nicolela
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Balwantray C Chauhan
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States
    Discoveries in Sight Research Laboratories, Legacy Devers Eye Institute at Legacy Good Samaritan Medical Center, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Hongli Yang None; Ya Xing Wang Heidelberg Engineering, Code F (Financial Support); JInwook Jeoung None; Seungwoo Hong None; Stuart Gardiner Heidelberg Engineering , Code F (Financial Support); Juan Reynaud None; Brad Fortune Legacy Good Samaritan Foundation, Code F (Financial Support), Inotek Pharmaceuticals, Code F (Financial Support); Michael Girard Abyss Processing Pte Ltd; , Code F (Financial Support); Glen Sharpe None; Marcelo Nicolela None; Balwantray Chauhan Heidelberg Engineering, Code F (Financial Support); Claude Burgoyne Heidelberg Engineering, Code F (Financial Support)
  • Footnotes
    Support  Legacy Good Samaritan Foundation
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4159. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Hongli Yang, Ya Xing Wang, JInwook Jeoung, Seungwoo Hong, Stuart Keith Gardiner, Juan Reynaud, Brad Fortune, Michael J A Girard, Glen Sharpe, Marcelo Nicolela, Balwantray C Chauhan, Claude F Burgoyne; Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4159.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To use optical coherence tomography (OCT) to 3D characterize optic nerve head (ONH) perineural canal (pNC) scleral bowing (pNC-SB) and pNC choroidal thickness (pNC-CT) in 69 highly myopic (38 healthy/31 glaucoma) and 138 healthy, age-matched, control eyes.

Methods : Each eye underwent enhanced depth, 24 radial B-scan OCT imaging, oriented relative to the Fovea-Bruch’s Membrane Opening (FoBMO) axis (Spectralis, Heidelberg Engineering). Within each radial B-scan, Bruch’s membrane (BM), BM opening (BMO), the anterior scleral canal opening (ASCO), and the pNC scleral surface were manually segmented. BMO and ASCO best fit planes and centroids were determined. pNC-SB was characterized within 30° FoBMO sectors (12 sectors per eye) by two parameters: pNC scleral slope (pNC-SB-SS) measured within three pNC segments (0-300, 300-700 and 700-1000 μm from the ASCO,Figure 1A); and ASCO depth relative to a pNC scleral reference plane at 1700 um from center of ASCO (pNC-SB- ASCOD). pNC-CT was calculated as the minimum distance between the scleral surface and BM at three pNC locations (300, 700, and 1100 μm from the ASCO, Figure 1B).

Results : pNC-SB increased and pNC-CT decreased with axial length and age among all study eyes (p<0.05, general linear model using general estimation equations [GEEGLM]). Both pNC-SB parameters were highest and pNC-CT was lowest within the inferior and inferior-temporal FoBMO sectors (p<0.0001, GEEGLM; Figure 2). pNC-SB was higher (ranging from 83% to 273%) and pNC-CT was lower (ranging from 21.9% to 41.9%) in the highly myopic compared to control eyes and these differences were greatest in the inferior FoBMO sectors. Sectoral pNC-SB was not related to sectoral pNC-CT within Control eyes (p=0.37, GEEGLM), but was inversely related to sectoral pNC-CT within the Highly Myopic eyes (p < 0.0001, GEEGLM) (Figure 1C).

Conclusions : Our study is the first to three-dimensionally characterize FoBMO sectoral pNC-SB and pNC-CT in highly myopic eyes. Our data suggests that pNC-SB is higher and confirms that pNC-CT is lower in highly myopic eyes. Because the sectors of maximum pNC-SB predict the sectors of minimum pNC-CT in the highly myopic eyes, our findings also suggest that: 1) there may be mechanistic links between these phenomena; and 2) sectors of maximum pNC-SB may predict the sectors of greatest susceptibility to aging and glaucoma in longitudinal studies of highly myopic eyes.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×