June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Evaluation of outer retinal layers in neovascular AMD comparing High-Res OCT and SPECTRALIS OCT imaging
Author Affiliations & Notes
  • Veronika Röggla
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Gregor Sebastian Reiter
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Philipp Fuchs
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Leonard Mana Coulibaly
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Sophie Frank
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Markus Gumpinger
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Oliver Leingang
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Hrvoje Bogunovic
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
    Christian Doppler Laboratory for Artificial Intelligence in Retina, Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Vienna, Austria, Austria
  • Ursula Schmidt-Erfurth
    Opthahlmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Veronika Röggla None; Gregor Reiter RetinSight, Vienna, Austria, Code F (Financial Support); Philipp Fuchs None; Leonard Coulibaly None; Sophie Frank None; Markus Gumpinger None; Oliver Leingang None; Hrvoje Bogunovic Heidelberg Engeneering, Code F (Financial Support), RetinSight, Vienna, Austria, Code F (Financial Support); Ursula Schmidt-Erfurth RetinSight, Vienna, Austria, Code F (Financial Support), RetinSight, Vienna, Austria, Code P (Patent)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 306. doi:
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      Veronika Röggla, Gregor Sebastian Reiter, Philipp Fuchs, Leonard Mana Coulibaly, Sophie Frank, Markus Gumpinger, Oliver Leingang, Hrvoje Bogunovic, Ursula Schmidt-Erfurth; Evaluation of outer retinal layers in neovascular AMD comparing High-Res OCT and SPECTRALIS OCT imaging. Invest. Ophthalmol. Vis. Sci. 2023;64(8):306.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of the study is to compare the visibility and accessibility of the outer retinal layers underneath fluid in neovascular age-related macular degeneration (nAMD) between the conventional SPECTRALIS OCT device and the High-Res OCT device.

Methods : Differences in thickness and loss of individual outer retinal layers in eyes with active nAMD between an investigational High-Res OCT device and the conventional SPECTRALIS HRA+OCT (both from Heidelberg Engineering GmbH, Heidelberg, Germany) were analyzed. Eyes with nAMD and at least 250nl of total fluid (IRF and SRF), detected by a validated deep-learning algorithm (Vienna Fluid Monitor, RetInSight, Austria), fulfilled inclusion criteria. After manual fovea annotation, the outer retinal layers (ELM, EZ, RPE) were segmented in the 50 central B-scans using artificial intelligence followed by manual correction. Additionally, for correct measurement of EZ thickness, subretinal fluid (SRF) and subretinal hyperreflective material (SHRM) were annotated (Figure 1). Layer loss and thickness were compared between both devices using Wilcoxon signed rank test.

Results : Fifteen eyes of 13 patients with active nAMD were included. Evaluating the central millimeter, the thickness of RPE differed significantly between the devices (26.18 ± 3.43 μm and 28.25 ± 4.42 μm for High-Res OCT and conventional OCT, respectively, p = 0.047). In the central 3 mm, a trend in the RPE thickness difference was observed (23.31 ± 2.72 μm and 25.93 ± 3.36 μm, respectively, p = 0.061). The mean thickness of EZ in the central 3 mm was 42.77 ± 10.58 μm and 42.75 ± 11.14 μm (p= 0.82) on High-Res OCT and conventional OCT, respectively, and did not differ significantly between devices. The mean relative RPE-loss, EZ loss, and as well as ELM loss did not differ significantly (p = 0.842, p = 0.510 and p = 0.691, respectively).

Conclusions : Central RPE thickness was significantly thinner on High-Res OCT compared to conventional OCT, which can be explained by better visible separation of RPE and Bruch’s membrane. High-Res OCT images can provide more detailed information on the outer retinal layers in exudative disease and therewith offer better opportunities for detecting the stage and progression of neovascular AMD.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

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