June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Valvular heart disease and subretinal drusenoid deposits in age-related macular degeneration
Author Affiliations & Notes
  • Sophie Chen
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Yang Fei
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Jason Joonho Jo
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Emanuel Mordechaev
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Brandon Le
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Yuehong Tong
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Katy Tai
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Roland Theodore Smith
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Sophie Chen None; Yang Fei None; Jason Jo None; Emanuel Mordechaev None; Brandon Le None; Yuehong Tong None; Katy Tai None; Roland Theodore Smith None
  • Footnotes
    Support  Regeneron Pharmaceuticals Investigator-Initiated Study, Research to Prevent Blindness Challenge Grant (RTS and RBR), Macula Foundation (KBF), Bayer-Global Ophthalmology Awards (GL-G), International Council of Ophthalmology-Alcon Fellowship (OO-M) and New York Eye and Ear Infirmary Foundation (SA).
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2748. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sophie Chen, Yang Fei, Jason Joonho Jo, Emanuel Mordechaev, Brandon Le, Yuehong Tong, Katy Tai, Roland Theodore Smith; Valvular heart disease and subretinal drusenoid deposits in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2748.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose :

A strong association between subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) and vascular disease, including valvular, non-atherosclerotic heart disease (VHD), was found in a study of 200 intermediate AMD (iAMD) subjects (Ledesma-Gil et al., BMJO, 2022). We report an expanded collection of VHD cases from that study acquired from subjects’ medical records for post-hoc analysis, linking VHD severity on transthoracic echocardiograms (TTEs) with SDDs.

Methods :
TTEs were available for 29 of the initial 200 subjects (mean=80.6±9.4 years old; 15 females). Retina specialists classified them as SDD (with or without soft drusen) or non-SDD (drusen only) based on spectral domain optical coherence tomography, autofluorescence, and near-infrared reflectance imaging. Subjects with valve repair surgery were excluded. TTE data included the Cardiac Index (CI) and the presence/grading of VHD subtypes. VHD was divided into trace or less VHD and mild or greater VHD. Associations between SDD status and VHD severity were calculated by a chi-square test. Mean CIs in SDD and non-SDD groups were compared by a one-tailed t-test.

Results :

Mild or greater VHD was significantly associated with SDD versus non-SDD groups, 68.4% and 30%, respectively, p=0.048, Figure. CI (L/min/m2) was calculated for the 20 subjects with adequate TTE data. The 14 subjects with SDDs had significantly lower mean CI than the six subjects without SDDs (1.81±0.34 versus 2.42±0.54, p=0.031). No significant correlations were found between SDDs and VHD severity or subtype (stenosis or regurgitation) in the four valves.

Conclusions :

In this small sub-study of iAMD subjects with valve disease and echocardiographic metrics of cardiac dysfunction, SDD presence was associated with VHD, greater degrees of valvular dysfunction, and lower CI, suggesting poor systemic perfusion secondary to valvular disease as a mechanism for SDDs.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 


Figure (reproduced with consent, Ledesma-Gil et al., BMJO, 2022) shows near-infrared reflectance (NIR) and spectral domain optical coherence tomography (SD-OCT) imaging of the left eye of a subject with severe aortic stenosis and pure subretinal drusenoid deposits (SDDs). (A) NIR depicts an SDD pattern of multiple hyporeflectant lesions. (B) SD-OCT scan (green arrow in A) displays a pure SDD phenotype with stage 2 lesions but no drusen, correlating the poor perfusion of the severe VHD with macular SDDs.


Figure (reproduced with consent, Ledesma-Gil et al., BMJO, 2022) shows near-infrared reflectance (NIR) and spectral domain optical coherence tomography (SD-OCT) imaging of the left eye of a subject with severe aortic stenosis and pure subretinal drusenoid deposits (SDDs). (A) NIR depicts an SDD pattern of multiple hyporeflectant lesions. (B) SD-OCT scan (green arrow in A) displays a pure SDD phenotype with stage 2 lesions but no drusen, correlating the poor perfusion of the severe VHD with macular SDDs.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×