June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Automated segmentation and quantification of calcified drusen on 3D swept-source OCT imaging
Author Affiliations & Notes
  • Jie Lu
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Yuxuan Cheng
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Jianqing Li
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
    Ophthalmology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
  • Ziyu Liu
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Mengxi Shen
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Qinqin Zhang
    Research and Development, Carl Zeiss Meditec Inc, Dublin, California, United States
  • Jeremy Liu
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Gissel Herrera
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Farhan E. Hiya
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Giovanni Gregori
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Philip J Rosenfeld
    Ophthalmology, University of Miami School of Medicine, Miami, Florida, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Jie Lu None; Yuxuan Cheng None; Jianqing Li None; Ziyu Liu None; Mengxi Shen None; Qinqin Zhang Carl Zeiss Meditec, Code E (Employment); Jeremy Liu None; Gissel Herrera None; Farhan Hiya None; Giovanni Gregori Carl Zeiss Meditec, Code F (Financial Support); Philip Rosenfeld Annexon, Apellis, Bayer, Boehringer-Ingelheim, Carl Zeiss Meditec, Chengdu Kanghong Biotech, InflammX, Ocudyne, Regeneron, Unity Biotechnology, Code C (Consultant/Contractor), Alexion, Carl Zeiss Meditec, Gyroscope Therapeutics, Stealth BioTherapeutics, Code F (Financial Support), Apellis, Ocudyne, Valitor, Verana Health, Code I (Personal Financial Interest); Ruikang Wang Carl Zeiss Meditec, Code C (Consultant/Contractor), Carl Zeiss Meditec, Colgate Palmolive Company, Estee Lauder Inc , Code F (Financial Support)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2370. doi:
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      Jie Lu, Yuxuan Cheng, Jianqing Li, Ziyu Liu, Mengxi Shen, Qinqin Zhang, Jeremy Liu, Gissel Herrera, Farhan E. Hiya, Giovanni Gregori, Philip J Rosenfeld, Ruikang K Wang; Automated segmentation and quantification of calcified drusen on 3D swept-source OCT imaging. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2370.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Qualitative and quantitative assessments of calcified drusen are clinically important for determining the risk of age-related macular degeneration (AMD) progression. This study aims to develop an automated algorithm to segment and quantify calcified drusen on swept-source optical coherence tomography (SS-OCT) images.

Methods : Eyes were included when present with drusen that contained hyperreflective contents with a hyperreflective cap and a hypo-reflective core or without a hypo-reflective accompanied by choroidal hypotransmission defects (hypoTDs) on the 6×6 mm macular SS-OCT volume imaging. Calcified drusen are characterized by a higher optical attenuation coefficient (OAC) compared with soft drusen, resulting in a hypoTD below the calcified drusen. The algorithm automatically segmented calcified drusen from 3D SS-OCT scans by combining the OAC within drusen and the hypoTDs under drusen. To validate and compare the outcomes from the proposed algorithm, the calcified drusen were manually outlined by identifying choroidal hypoTDs on subRPE slabs extending 64 to 400 um below Bruch’s membrane (BM) combined with hyperreflective contents within drusen on B-scans.

Results : A total of 29 eyes with nonexudative AMD and calcified drusen were included to test the performance of the automated algorithm. The algorithm achieved good agreement with the human expert graders in identifying the area of calcified drusen (Dice similarity coefficient: 68.27 ± 11.09 %, correlation coefficient: r = 0.9422, Fig.1.)

Conclusions : A novel strategy is developed and tested that can segment and quantify calcified drusen via the use of its high optical scattering properties and the characteristic hypoTDs observed in slabs below BM.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

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