June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Ultra-Widefield Imaging of Vitreous Base-associated Vasculopathy: An Assessment of Peripheral Retinal Hemorrhages and Microaneurysms
Author Affiliations & Notes
  • Yilin Feng
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Aaron Fairbanks
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Sandra Hoyek
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Natalie Huang
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Nimesh Patel
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Yilin Feng None; Aaron Fairbanks None; Sandra Hoyek None; Natalie Huang None; Nimesh Patel Atheneum, Alcon, Allergan, Alimera, Eyepoint, Lifesciences, Genentech, Guidepoint, Regeneron, Code C (Consultant/Contractor)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2074. doi:
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      Yilin Feng, Aaron Fairbanks, Sandra Hoyek, Natalie Huang, Nimesh Patel; Ultra-Widefield Imaging of Vitreous Base-associated Vasculopathy: An Assessment of Peripheral Retinal Hemorrhages and Microaneurysms. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2074.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The underlying etiology of peripheral retinal hemorrhages and peripheral microaneurysms is unknown and subject to debate. In this study, we aim to describe cases of asymptomatic peripheral retinal hemorrhage or microaneurysms attributed solely to presumed vitreous base traction using ultra-widefield imaging (UWFI).

Methods : This is a retrospective, consecutive series of asymptomatic patients with peripheral retinal hemorrhage or microaneurysms. UWF fundus photography, fundus autofluorescence, fluorescein angiography, and/or optical coherence tomography were obtained.

Results : We report nine adult cases with asymptomatic peripheral retinal hemorrhages and/or microaneurysms. These findings were observed on a routine eye examination or as an incidental finding in the contralateral eye of patients presenting a retinal break or detachment. On UWFI, the distinguishing features of peripheral retinal hemorrhage and microaneurysms due to vitreous base traction comprised their pinpoint shape and their location at the vitreous base, particularly in the far temporal and superior retinal periphery. UWF fluorescein angiography showed punctate hyperfluorescent spots with minimal to no leakage. Optical coherence tomography demonstrated signs of evolving posterior vitreous detachment. Management was limited to observation, with stable microaneurysms and resolution of hemorrhages with time.

Conclusions : UWFI has led to the identification of vitreous base vasculopathy. Observation is appropriate in these cases if targeted workup is unrevealing.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. Color fundus photographs, autofluorescence and fluorescein angiography in patients with asymptomatic bilateral peripheral retinal hemorrhages. Case 1 - Color fundus photographs and fundus autofluorescence of the right (A, E) and left (B, F) eyes display peripheral temporal dot-blot hemorrhages and microaneurysms. Fluorescein angiography of the right (I) and left (J) eyes demonstrate pinpoint dilations and far temporal leakage without avascularity or significant vasculitis. Case 2 - Color fundus photographs and fundus autofluorescence of the right (C, G) and left (D, H) eyes show retinal hemorrhages in areas of white without pressure in the far temporal peripheral retina. Fluorescein angiography of the right (K) and left (L) eyes reveal pinpoint hyperfluorescent staining in the temporal periphery without avascularity or leakage.

Figure 1. Color fundus photographs, autofluorescence and fluorescein angiography in patients with asymptomatic bilateral peripheral retinal hemorrhages. Case 1 - Color fundus photographs and fundus autofluorescence of the right (A, E) and left (B, F) eyes display peripheral temporal dot-blot hemorrhages and microaneurysms. Fluorescein angiography of the right (I) and left (J) eyes demonstrate pinpoint dilations and far temporal leakage without avascularity or significant vasculitis. Case 2 - Color fundus photographs and fundus autofluorescence of the right (C, G) and left (D, H) eyes show retinal hemorrhages in areas of white without pressure in the far temporal peripheral retina. Fluorescein angiography of the right (K) and left (L) eyes reveal pinpoint hyperfluorescent staining in the temporal periphery without avascularity or leakage.

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