June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Clinical validation of simulated multifocal intraocular lenses. SimVis GekkoTM simulations and reports on pseudophakic patients
Author Affiliations & Notes
  • Amal Zaytouny
    INSTITUTE OF OPTICS, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
  • Irene Sisó-Fuertes
    2Eyes Vision, Madrid, Spain
  • Xoana Barcala
    2Eyes Vision, Madrid, Spain
  • Lucie Sawides
    2Eyes Vision, Madrid, Spain
  • Carlos Dorronsoro
    INSTITUTE OF OPTICS, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    2Eyes Vision, Madrid, Spain
  • Susana Marcos
    INSTITUTE OF OPTICS, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Center for Visual Science; Flaum Eye Institute, The Institute of Optics, University of Rochester, New York, United States
  • Footnotes
    Commercial Relationships   Amal Zaytouny None; Irene Sisó-Fuertes 2Eyes Vision, Code E (Employment); Xoana Barcala 2Eyes Vision, Code E (Employment); Lucie Sawides 2Eyes Vision, Code E (Employment); Carlos Dorronsoro 2Eyes Vision, Code E (Employment), 2Eyes Vision, Code I (Personal Financial Interest), 2Eyes Vision. P201331436, US2012075585, Code P (Patent); Susana Marcos 2Eyes Vision, Code I (Personal Financial Interest), 2Eyes Vision. P201331436, US2012075585, Code P (Patent)
  • Footnotes
    Support  Spanish Government PID2020-115191RB-I00; P30 Core Grant EY001319-46; IND2020/BMD-17442; Unrestricted grant Research to Prevent Blindness (Flaum Eye Institute, University of Rochester, NY)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5421. doi:
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      Amal Zaytouny, Irene Sisó-Fuertes, Xoana Barcala, Lucie Sawides, Carlos Dorronsoro, Susana Marcos; Clinical validation of simulated multifocal intraocular lenses. SimVis GekkoTM simulations and reports on pseudophakic patients. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5421.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The increasing number of commercially available intraocular lenses (IOLs) makes selecting the optimal design for each patient challenging. SimVisGekko (2EyesVision, Madrid, Spain) is a binocular see-through visual simulator that allows patients to experience the vision with different corrections before surgery. We performed an observational, non-interventional study to compare through focus (TF) performance of simulated multifocal IOLs (MIOLs) through SimVisGekko (SVG) and that reported from patients implanted with the corresponding MIOLs.

Methods : Six MIOLs were programmed in SVG: Symfony (J&J), PanOptix and Vivity (Alcon), FineVision (PhysIOL), ATLisa tri and ATLara (ZEISS). The MIOLs were programmed by optotunable lens temporal multiplexing, using published on bench TF optical quality. Binocular TF logMAR Visual Acuity (TFVA) curves were measured through the simulated designs in 23 presbyopes (15 per lens group, age: 55±5 yo). Postoperative TFVA curves from patients implanted with the same MIOLs were compiled from scientific literature, and compared with the TFVA measured through the SVG-simulated MIOLs. Comparisons were made in terms of TFVA shape similarity (cross-correlation) and Root Mean Square (RMS) difference.

Results : The TFVA shape similarity between simulated and real IOLs was 0.96/0.84/0.90/0.99/0.96/0.97, and the RMS difference was 0.07/0.03/0.04/0.05/0.10/0.12 µm for the Symfony, PanOptix, Vivity, FineVision, ATLisa tri and ATLara IOLs respectively (Figure 1). Simulated TFVA curves and those from implanted patients overlapped their standard deviation in 92% of the defocus and were, on average, statistically similar in 84.3% of the measured dioptric range in 4 of the 6 MIOLs.

Conclusions : The match between TFVA measured in presbyopic subjects through the SVG-simulated MIOLs and pseudophakic patients implanted with the same real MIOLs suggests that commercial corrections can be programmed in SVG using public data and be reliably validated in patients. These findings demonstrate that SVG can accurately reproduce the real vision through the Symfony, PanOptix, FineVision, Vivity, ATLisa tri and ATLara MIOLs, and predict their postoperative performance when used in the clinical practice

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

TFVA curves of SVG simulated MIOLs (colored) and averaged visual performance as obtained from the literature on patients implanted with the corresponding real MIOLs (black)

TFVA curves of SVG simulated MIOLs (colored) and averaged visual performance as obtained from the literature on patients implanted with the corresponding real MIOLs (black)

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