June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Diagnostic Ability of Optical Coherence Tomography Angiography Macular Vessel Density for Glaucoma in Individuals of African and European Descent
Gopikasree Gunasegaran; Sasan Moghimi; Takashi Nishida; Evan Walker; Alireza Kamalipour; Jo-Hsuan Wu; Golnoush Mahmoudinezhad; Linda M Zangwill; Robert N Weinreb
Author Affiliations & Notes
  • Gopikasree Gunasegaran
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Sasan Moghimi
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Takashi Nishida
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Evan Walker
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Alireza Kamalipour
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Jo-Hsuan Wu
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Golnoush Mahmoudinezhad
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Linda M Zangwill
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Robert N Weinreb
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Gopikasree Gunasegaran None; Sasan Moghimi National Eye Institute, University of California Tobacco-Related Disease Research Program , Code F (Financial Support); Takashi Nishida Topcon, Code C (Consultant/Contractor); Evan Walker None; Alireza Kamalipour Fight For Sight , Code F (Financial Support); Jo-Hsuan Wu None; Golnoush Mahmoudinezhad None; Linda Zangwill Abbvie, Topcon, Code C (Consultant/Contractor), National Eye Institute, Carl Zeiss Meditec, Optovue, Heidelberg Engineering, Topcon, Code F (Financial Support), Carl Zeiss Meditec, Code P (Patent); Robert Weinreb Abbvie, Aerie Pharmaceuticals, Allergan, Amydis, Equinox, Eyenovia, Iantrek, IOPtic, Implandata, Nicox, Topcon, Code C (Consultant/Contractor), National Eye Institute, Heidelberg Engineering, Carl Zeiss Meditec, Konan Medical, Optovue, Zilia, Centervue, Topcon, Code F (Financial Support), Toromedes, Carl Zeiss Meditec, Code P (Patent)
  • Footnotes
    Support   National Eye Institute R01EY034148, R01EY029058, R01EY11008, R01EY19869, R01EY027510, R01EY026574, EY018926 P30EY022589; Fight for Sight Foundation; Tobacco-Related Disease Research Program T31IP1511; Unrestricted grant from Research to Prevent Blindness (New York, NY)
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4423. doi:
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      Gopikasree Gunasegaran, Sasan Moghimi, Takashi Nishida, Evan Walker, Alireza Kamalipour, Jo-Hsuan Wu, Golnoush Mahmoudinezhad, Linda M Zangwill, Robert N Weinreb; Diagnostic Ability of Optical Coherence Tomography Angiography Macular Vessel Density for Glaucoma in Individuals of African and European Descent. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4423.

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Abstract

Purpose : To evaluate diagnostic accuracy of macular vessel density (VD) measured by optical coherence tomography angiography (OCTA) in individuals of African descent (AD) and European descent (ED) with open-angle glaucoma.

Methods : In this cross-sectional study, 176 eyes of 123 glaucoma patients and 140 eyes of 88 healthy participants from the Diagnostic Innovations in Glaucoma Study were included. Whole-image ganglion cell complex (wiGCC) thickness and macular VD (parafoveal VD and perifoveal VD) were obtained from 6*6 macula scans. Area under the receiver operating characteristic (AUROC) curves were used to evaluate the diagnostic accuracy of macular VD and GCC thickness in AD and ED participants after adjusting for confounders such as age, severity of glaucoma as summarized by visual field mean deviation (VF MD), signal strength index (SSI) and axial length (AL).

Results : Parafoveal and perifoveal VD were significantly lower in glaucoma patients of ED than in glaucoma patients of AD. Parafoveal VD performed significantly worse in AD participants compared to ED participants for detection of glaucoma (adjusted AUROC, 0.75 [95% CI, 0.62, 0.87], 0.85 [95% CI, 0.78, 0.91], respectively; P= 0.035). Perifoveal VD showed similar findings (adjusted AUROC, 0.82 [95% CI, 0.70, 0.92], 0.91 [95% CI, 0.87, 0.94], respectively; P= 0.020). GCC thickness had similar diagnostic accuracy between AD and ED individuals (adjusted AUROC, 0.89 [95% CI, 0.79, 0.96], 0.92 [95% CI, 0.86, 0.96], respectively; P= 0.313). The diagnostic accuracies of parafoveal VD, perifoveal VD, and GCC thickness for differentiating between glaucoma and healthy eyes increased with increasing severity of glaucoma in both AD and ED participants.

Conclusions : Diagnostic performance of OCTA macular VD for glaucoma detection varies by race while the diagnostic performance of GCC thickness did not vary by race. In particular, macular VD parameters may have limited value for diagnosing glaucoma in AD individuals.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. AUROC curves for parafoveal VD, perifoveal VD and GCC thickness for differentiating glaucoma from healthy eyes
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Figure 1. AUROC curves for parafoveal VD, perifoveal VD and GCC thickness for differentiating glaucoma from healthy eyes

Figure 1. AUROC curves for parafoveal VD, perifoveal VD and GCC thickness for differentiating glaucoma from healthy eyes

Figure 1. AUROC curves for parafoveal VD, perifoveal VD and GCC thickness for differentiating glaucoma from healthy eyes
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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