June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
WITHDRAWN_Cross-sectional and longitudinal associations of chronic kidney disease with neurodegeneration: evidence from the UK Biobank and a Chinese cohort
Author Affiliations & Notes
  • xiao guo
    Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China
  • Wenyong Huang
    Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China
  • Wei Wang
    Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China
  • Mingguang He
    Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China
  • Footnotes
    Commercial Relationships   xiao guo None; Wenyong Huang None; Wei Wang None; Mingguang He None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4198. doi:
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      xiao guo, Wenyong Huang, Wei Wang, Mingguang He; WITHDRAWN_Cross-sectional and longitudinal associations of chronic kidney disease with neurodegeneration: evidence from the UK Biobank and a Chinese cohort. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4198.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Chronic kidney disease (CKD) is a risk factor for neurodegenerative diseases (NDDs), and ganglion cell-inner plexiform layer (GCIPL) thickness is considered an early and sensitive biomarker for NDDs. As previous studies have yielded conflicting results, this study aimed to assess the effect of CKD on GCIPL thickness.

Methods : This multiethnic, prospective observational cohort study collected 23,014 non-NDDs of more than 500,000 individuals from the UK Biobank, and three years of continuous follow-up data of 2,197 individuals from a Chinese cohort. GCIPL thickness was measured using OCT, and CKD was graded by calculating the eGFR.

Results : In the cross-sectional analysis, poorer renal function negatively correlated with GCIPL thickness with the mean decrease of 0.15 μm (95% CI -0.30 to -0.01; p=0.038) in mild CKD, and 0.83 μm (95% CI -1.34 to -0.32; p=0.002) in MS-CKD, both compared to that of controls without CKD. Longitudinal analysis showed that the GCIPL decreased more rapidly in persons with poorer renal function. After correcting for confounders, the rate of GCIPL decline accelerated significantly as the CKD severity increased, by 0.30 μm/year (95% CI -0.41 to -0.19; p<0.001) in mild CKD patients and by 0.52 μm/year (95% CI -0.79 − -0.26; p<0.001) in MS-CKD, both compared to controls without CKD. This relationship remained significant in individuals with diabetes or hypertension.

Conclusions : The degree of renal impairment was negatively associated with GCIPL thickness and renal impairment accelerated the rate at which GCIPL thickness decreased over time.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Fig 1. Overall workflow of the cohort study; scientific and clinical problems.

Fig 1. Overall workflow of the cohort study; scientific and clinical problems.

 

Fig 2. Overall distribution of the study population.
A total of 25,301 individuals from two large cohorts in the United Kingdom and China were included. Of 23,104 individuals without eye disease in the UK Biobank cohort, 22,032 were non-diabetic, and 21,085 were Caucasian. The COIP cohort included three-year follow-up data from 2,197 individuals without ocular disease.

Fig 2. Overall distribution of the study population.
A total of 25,301 individuals from two large cohorts in the United Kingdom and China were included. Of 23,104 individuals without eye disease in the UK Biobank cohort, 22,032 were non-diabetic, and 21,085 were Caucasian. The COIP cohort included three-year follow-up data from 2,197 individuals without ocular disease.

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