June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Impact of baseline classification on rates of sectoral glaucomatous neuroretinal rim and nerve fibre layer change
Author Affiliations & Notes
  • Brooklyn Rawlyk
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
    University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada
  • Glen Sharpe
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Donna M Hutchison
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Lesya M Shuba
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Marcelo Nicolela
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Balwantray C Chauhan
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Footnotes
    Commercial Relationships   Brooklyn Rawlyk None; Glen Sharpe None; Donna Hutchison None; Lesya Shuba None; Marcelo Nicolela Allergan Inc., Heidelberg Engineering , Code F (Financial Support), Bausch and Lomb, Canada, Code R (Recipient); Balwantray Chauhan Heidelberg Engineering, iCare, Topcon Inc., Code F (Financial Support), iCare, Code R (Recipient)
  • Footnotes
    Support  Canadian Institutes of Health Research grant MOP-11357; Gordan and Jean Hayman Glaucoma Research Studentship
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3436. doi:
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    • Get Citation

      Brooklyn Rawlyk, Glen Sharpe, Donna M Hutchison, Lesya M Shuba, Marcelo Nicolela, Balwantray C Chauhan; Impact of baseline classification on rates of sectoral glaucomatous neuroretinal rim and nerve fibre layer change. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3436.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine whether the baseline classification (BC) of sectoral neuroretinal minimal rim width (MRW) and peripapillary retinal nerve fibre layer thickness (RNFLT) impacted the ability to determine further change due to a floor effect.

Methods : Data were obtained from a prospective study of glaucoma patients imaged at 6-month intervals. The MRW and RNFLT values of one study eye per patient at each visit were derived from optical coherence tomography (Spectralis OCT2, Heidelberg Engineering) scans oriented and analysed in fovea to Bruch’s membrane opening angle coordinates. We determined sectoral MRW and RNFLT change as a function of BC (within normal limits [WNL], baseline [BL] and outside normal limits [ONL]) with least squares regression.

Results : The study contained 119 patients with median age of 71.2 years age, visual field mean deviation of -4.31 dB, follow-up of 6.9 years with 14 follow-up visits. For MRW, sectoral BC of WNL, BL and ONL varied from 17%-47%, 16%-30% and 34%-67%, respectively. The corresponding BC for RNFLT were 16%-61%, 10-29% and 10%-73%. For all sectors, the rate of both MRW and RNFLT change was weakly related to the corresponding baseline values (Fig. 1). There was no difference in the rate of sectoral MRW change among BC groups, except for inferior nasal and no differences in the proportion of statistically significant slopes among the BC groups (Fig. 2). In slight contrast, rates of temporal, superior temporal and superior nasal RNFLT change were significantly different among the BC groups with WNL having the largest change and ONL the least. Furthermore, a greater number of slopes in the superior temporal and superior nasal quadrants were significant (Fig. 2).

Conclusions : There was little evidence to suggest that further changes in MRW cannot be detected in sectors with a baseline ONL classification. There was a tendency for RNFLT to demonstrate a weak floor effect in some sectors.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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