June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Characterization of Sustained Increases in Intraocular Pressure After Aflibercept in Prefilled and Vial Draw Syringes.
Author Affiliations & Notes
  • Neil Akash Rana
    Case Western Reserve University School of Medicine, Cleveland, Ohio, United States
  • Matthew W Russell
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States
    Center for Ophthalmic Bioinformatics, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
  • Meghana Chalasani
    Northeast Ohio Medical University, Rootstown, Ohio, United States
  • Justin Muste
    Center for Ophthalmic Bioinformatics, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
    Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
  • Rishi P Singh
    Center for Ophthalmic Bioinformatics, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
    Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
  • Sumit Sharma
    Center for Ophthalmic Bioinformatics, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
    Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Neil Rana None; Matthew Russell None; Meghana Chalasani None; Justin Muste None; Rishi Singh Genentech/Roche, Alcon, Novartis, Regeneron, Asclepix, Gyroscope, Bausch and Lomb, Apellis, Code I (Personal Financial Interest); Sumit Sharma AbbVie, Alimera, Bausch & Lomb, EyePoint, Regeneron, Genentech/Roche, Clearside, Code C (Consultant/Contractor), Gilead, Genentech/Roche, Santen, IONIS, Code F (Financial Support)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2706. doi:
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      Neil Akash Rana, Matthew W Russell, Meghana Chalasani, Justin Muste, Rishi P Singh, Sumit Sharma; Characterization of Sustained Increases in Intraocular Pressure After Aflibercept in Prefilled and Vial Draw Syringes.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2706.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Several studies have found intravitreal anti-VEGF injections to be associated with chronic intraocular pressure (IOP) elevation. Furthermore, delivery of these injections with prefilled syringes (PFS) may be associated with higher rates of sustained IOP increases compared to vial draw delivery. The purpose of this study is to evaluate the effect of syringe type on the development of sustained increases in IOP among patients receiving aflibercept injections in a single tertiary care center.

Methods : A retrospective cohort study was completed on patients receiving aflibercept injections at the Cole Eye Institute from 2012-2022. Patients were grouped as either having received vial draw injections or prefilled syringe injections for aflibercept treatment. IOP measurements and number of subsequent injections were recorded for one year following treatment initiation. The primary outcome measure was sustained increase in intraocular pressure, defined as ≥5 mmHg above baseline for at least 4 weeks. Secondary outcome measures included development of ocular hypertension and glaucoma.

Results : Six of 305 total eyes (1.9%) developed sustained IOP increases throughout the study duration. No significant differences were observed with respect to prefilled versus vial draw syringe status on development of sustained IOP increases or ocular hypertension (1.6% vs 2.3%, p>0.05, 3.9% vs 9.5%, p>0.05 respectively).

Conclusions : This study finds an overall low incidence of sustained IOP increases in patients treated with aflibercept. Furthermore, syringe status was not found to be a relevant factor in sustained IOP increases. This study adds to existing literature challenging the associations between intravitreal injection and ocular pressure abnormalities.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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