June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Quantification of intermittent retinal capillary perfusion in retinal vein occlusion and proliferative diabetic subjects
Author Affiliations & Notes
  • Mahadev Bhalla
    Department of Ophthalmology, The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada
  • Arman Athwal
    Institute of Ophthalmology, University College London, London, London, United Kingdom
    Medical Physics and Biomedical Engineering, University College London, London, London, United Kingdom
  • Farhad Ghaseminejad
    The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada
  • sherry han
    Department of Ophthalmology, The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada
  • Derek Chan
    The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada
  • Marinko Sarunic
    Institute of Ophthalmology, University College London, London, London, United Kingdom
    Engineering Science, Simon Fraser University Faculty of Applied Sciences, Burnaby, British Columbia, Canada
  • Myeong Jin Ju
    Department of Ophthalmology, The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada
  • Eduardo Navajas
    Department of Ophthalmology, The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada
  • Footnotes
    Commercial Relationships   Mahadev Bhalla None; Arman Athwal None; Farhad Ghaseminejad None; sherry han None; Derek Chan None; Marinko Sarunic Seymour Vision, Code I (Personal Financial Interest); Myeong Jin Ju None; Eduardo Navajas None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2554. doi:
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      Mahadev Bhalla, Arman Athwal, Farhad Ghaseminejad, sherry han, Derek Chan, Marinko Sarunic, Myeong Jin Ju, Eduardo Navajas; Quantification of intermittent retinal capillary perfusion in retinal vein occlusion and proliferative diabetic subjects. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2554.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the use of optical coherence tomography angiography (OCTA) in capturing quantitative dynamic vascular changes in branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), proliferative diabetic retinopathy (PDR) and control eyes.

Methods : The study was approved by the ethics committee of the University of British Columbia. OCTA images of the macula and temporal to the macula area were acquired using the Zeiss Plex Elite 9000 from 4 groups: BRVO (n=10, age=72.96 ± 5.96 years, M:F = 7:3), CRVO (n=11, age=64.22 ± 13.32 years, M:F=4:7), PDR (n=9, age=54.38 ± 14.39 years, M:F=5:4) and normal controls (n=10, age=47.45 ± 19.26 years, M:F=5:5). Five repeat 6x6mm scans were acquired at a baseline time point (T0) and thirty minutes after (T30) at the two locations. Images from each time point were registered and averaged. Pixels were labeled as vessel or non-vessel using a previously published machine learning model. Two measures of capillary flow were calculated: Loss of Perfusion (LoP) defined as the percent of vessel pixels present in T0 image not present in T30, and Gain of Perfusion (GoP) defined as the percent of vessel pixels present in T30 image not present in T0 image.

Results : Qualitatively, regions of capillary perfusion and dropout across time-points could be observed amongst all groups, including the control group. All diseased groups showed significant difference compared to controls (p<0.05) in the temporal region for LoP (BRVO: 12.5 ± 8.4%, PDR: 15.6 ± 13.7%, CRVO: 10.3 ± 5.7%, Control: 4.9 ± 3.3%) and PDR and CRVO showed significant difference for GoP (PDR: 17.3 ± 8.0%, CRVO: 18.2 ± 13.9%, Control: 5.7 ± 4.0%). Only the PDR group showed significant difference compared to controls (p<0.05) in the macula region for GoP (PDR: 16.2 ± 13.1%, Control: 4.6 ± 3.6%) while both PDR and CRVO showed significant difference for LoP (PDR: 17.3 ± 8.0%, CRVO: 7.3 ± 2.9%, Control: 4.8 ± 3.6%). There was no significant difference between diseased groups in either region.

Conclusions : Our results highlight significant dynamic variation of capillary perfusion in BRVO, CRVO, and PDR patients compared to controls. Monitoring the vaso-occlusive burden, especially in the temporal region in patients, could provide utility in monitoring of the disease and in evaluating treatment efficacy.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

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