June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Decreased retinal capillary density as a beneficial response to 24-week high speed circuit resistance training in healthy older adults
Author Affiliations & Notes
  • Ava-Gaye Simms
    Ophthalmology, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Rosalia Parrino
    Kinesiology and Sports Sciences, University of Miami, Coral Gables, Florida, United States
  • Jianhua Wang
    Ophthalmology, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Hong Jiang
    Ophthalmology, University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Joseph F Signorile
    Kinesiology and Sports Sciences, University of Miami, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Ava-Gaye Simms None; Rosalia Parrino None; Jianhua Wang None; Hong Jiang None; Joseph F Signorile None
  • Footnotes
    Support  This study was supported by the University of Miami Provost's Research Award (Signorile, Jiang, Wang), NIH Center Grant P30 EY014801, NINDS 1R01NS111115-01 (Wang), the Ed and Ethel Moor Alzheimer’s Disease Research Program (Florida Health, 20A05, to Jiang) and a grant from Research to Prevent Blindness (RPB).
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2544. doi:
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    • Get Citation

      Ava-Gaye Simms, Rosalia Parrino, Jianhua Wang, Hong Jiang, Joseph F Signorile; Decreased retinal capillary density as a beneficial response to 24-week high speed circuit resistance training in healthy older adults. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2544.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the changes in retinal microvascular density after a 24-week high-speed circuit resistance training program (HSCT) in healthy older adults.

Methods : Thirty healthy older adults were recruited and randomly assigned to either a training group (HSCT) or a non-training (CON) group. Fifteen subjects (age 73.3 ± 7.76 yrs) in the HSCT group exercised three times per week on non-consecutive days for 24-weeks. Fifteen subjects in the CON group (age 72.2 ± 6.04 yrs) did not have formal physical training. Both eyes of each subject were imaged using optical coherence tomography angiography (OCTA) at baseline and at the 24-week follow-up. The vessel densities of the retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP) were measured.

Results : There were no demographic differences between study groups. There were significant decreases in the retinal vessel densities of RVN, SVP, DVP and in the HSCT group (P < 0.05, Fig. 1); however, there were no significant changes in any of the three vascular measurements in the CON group. Interestingly, the decreased vessel densities were double in the HSCT group, compared to the CON group, however, the differences between groups did not reach a significant level.

Conclusions : This is the first study to reveal the decreased retinal vessel densities as a possible imaging marker for the beneficial effects of the 24-week HSCT program in older adults.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. Retinal vessel densities of the HSCT and CON groups at baseline and 24-week follow-up. There were significant decreases in the retinal vessel densities of RVN, SVP and DVP in the HSCT group (P < 0.05). However, there were no significant changes of all three vascular measurements in the CON group (P > 0.05), although the changes showed a decreasing trend. HSCT: high-speed circuit training group; CON: control group VD: vessel density; RVD: VD in the total retinal vascular network; SVD: VD in the superficial vessel plexus; DVD: VD in the deep vessel plexus. Bars = standard errors.

Figure 1. Retinal vessel densities of the HSCT and CON groups at baseline and 24-week follow-up. There were significant decreases in the retinal vessel densities of RVN, SVP and DVP in the HSCT group (P < 0.05). However, there were no significant changes of all three vascular measurements in the CON group (P > 0.05), although the changes showed a decreasing trend. HSCT: high-speed circuit training group; CON: control group VD: vessel density; RVD: VD in the total retinal vascular network; SVD: VD in the superficial vessel plexus; DVD: VD in the deep vessel plexus. Bars = standard errors.

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