June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Structure-Function correlation between sectorial OCT parameters and corresponding mean sensitivity values obtained with IMOvifa and Humphrey Field Analyzer perimeters
Author Affiliations & Notes
  • Rafaella Nascimento e Silva
    Genentech Inc, South San Francisco, California, United States
  • Julia Anne Kim
    Genentech Inc, South San Francisco, California, United States
  • Dolly Chang
    Genentech Inc, South San Francisco, California, United States
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Joyce Kang
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • Yihao Li
    Genentech Inc, South San Francisco, California, United States
  • Chen Chen
    Genentech Inc, South San Francisco, California, United States
  • Yan Zhao
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • Sofia De Arrigunaga
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • Sandra Freeman
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • Kanza Aziz
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • David S. Friedman
    Massachusetts Eye and Ear, Department of Ophthalmology, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Rafaella Nascimento e Silva Genentech, Inc., Code E (Employment); Julia Kim Genentech, Inc., Code E (Employment); Dolly Chang Genentech Inc., Code E (Employment); Joyce Kang None; Yihao Li Genentech, Inc., Code E (Employment); Chen Chen Genentech, Inc., Code E (Employment); Yan Zhao None; Sofia De Arrigunaga None; Sandra Freeman None; Kanza Aziz None; David Friedman Thea, Code C (Consultant/Contractor), Genentech, Inc., Code F (Financial Support)
  • Footnotes
    Support  Genentech, Inc. provided financial support for the study and participated in the study design; management, analysis, and interpretation of the data
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2019. doi:
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    • Get Citation

      Rafaella Nascimento e Silva, Julia Anne Kim, Dolly Chang, Joyce Kang, Yihao Li, Chen Chen, Yan Zhao, Sofia De Arrigunaga, Sandra Freeman, Kanza Aziz, David S. Friedman; Structure-Function correlation between sectorial OCT parameters and corresponding mean sensitivity values obtained with IMOvifa and Humphrey Field Analyzer perimeters. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2019.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : IMOvifa is a portable perimeter which performs visual field testing with non-occlusion conditions and no requirement of a dark room. This study compared the structure-function correlation between optical coherence tomography (OCT) thickness parameters and the corresponding sectorial mean sensitivity (MS) values obtained with IMOvifa and Humphrey Field Analyzer (HFA) perimeters in suspects, glaucoma and ocular hypertension diagnosis patients.

Methods : Patients underwent IMOvifa 24-2 AIZE (CREWT Medical Systems, Inc., Tokyo, Japan), HFA 24-2 SITA-Standard (Carl Zeiss, Meditec, Dublin, CA, USA) and OCT tests within 12 weeks. Based on the Garway-Heath map, the 24-2 sensitivity points were divided in regions by the corresponding OCT peripapillary retinal nerve fiber layer (pRNFL) sectors, and also the central 10° points corresponding ganglion cell–inner plexiform layer thickness over the macula (mGCIPL). Then, the points were averaged after converting to linear scale and converted again on dB. The structure-function correlations were analyzed by Spearman’s rank coefficient and compared by Steiger’s test.

Results : A total of 57 eyes of 57 patients with reliable field results and adequate OCT strength were included in this analysis. IMOvifa had significantly shorter duration (3.7 vs 5.3 mins), different mean deviation (MD, difference -0.6dB), and visual field index (VFI, difference +1.0%) values as compared to HFA (p<0.001 for all). There was a moderate to strong correlation between IMOvifa and HFA MS sectors (p<0.001 for all, Figure). IMOvifa had significant correlations in the inferior (I,rho=0.46), superior (S,rho=0.45), and temporal (T, rho=0.28) pRNFL sectors and in the I (rho=0.63) and S (rho=0.53) mGCPIPL hemispheres (p≤0.03 for all). There was no significant difference in the correlation strength of IMOvifa vs HFA with OCT parameters (p≥0.06, Table).

Conclusions : The IMOvifa perimeter had a shorter duration time and different MD and VFI values than HFA. All MS sectors had a moderate to strong correlation between the devices. Function-structure correlations were similar when using either perimeter.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Scatterplots of MS obtained with IMOvifa and HFA by each corresponding sectorial OCT parameter.

Scatterplots of MS obtained with IMOvifa and HFA by each corresponding sectorial OCT parameter.

 

Structure-Function correlation between sectorial OCT parameters and corresponding MS values.

Structure-Function correlation between sectorial OCT parameters and corresponding MS values.

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