June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Pigment epithelial detachment composition indices in central serous chorioretinopathy using a novel image analysis technique
Author Affiliations & Notes
  • Sanya Yadav
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Joshua Ong
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Arman Zarnegar
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Amrish Selvam
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Manan Patel
    BJ Medical College Institute of Medical Post-Graduate Studies and Research, Ahmedabad, Gujarat, India
  • Ahan Banker
    BJ Medical College Institute of Medical Post-Graduate Studies and Research, Ahmedabad, Gujarat, India
  • Matthew Driban
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Supriya Arora
    Bahamas Vision Center, Princess Margaret Hospital Cancer Centre, Nassau, NP, Bahamas
  • Kiran Kumar Vupparaboina
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Sumit Randhir Singh
    Nilima Sinha Medical College and Hospital, Medhapura, Bihar, India
  • Jay Chhablani
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Sanya Yadav None; Joshua Ong None; Arman Zarnegar None; Amrish Selvam None; Manan Patel None; Ahan Banker None; Matthew Driban None; Supriya Arora None; Kiran Vupparaboina None; Sumit Singh None; Jay Chhablani Salutaris, Allergan, Novartis, Erasca, Code C (Consultant/Contractor)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4674. doi:
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      Sanya Yadav, Joshua Ong, Arman Zarnegar, Amrish Selvam, Manan Patel, Ahan Banker, Matthew Driban, Supriya Arora, Kiran Kumar Vupparaboina, Sumit Randhir Singh, Jay Chhablani; Pigment epithelial detachment composition indices in central serous chorioretinopathy using a novel image analysis technique. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4674.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Retinal pigment epithelial (RPE) changes and pigment epithelial detachments (PEDs) are often implicated in central serous chorioretinopathy (CSCR) pathophysiology. However, techniques to extract and quantify PED characteristics and investigate their role as biomarkers in CSCR are underrepresented in literature. We present a novel computational approach to quantify PED composition indices (PEDCI-S: serous, PEDCI-N: neovascular, PEDCI-F: fibrous) in CSCR and track changes over time.

Methods : 34 eyes with active CSCR and devoid of comorbid macular diseases were analyzed quarterly over a 1-year period. Patients were classified into acute or chronic CSCR based on symptom duration at the time of presentation. PEDs on OCT scans were manually segmented and then filtered using 2D kernels to identify regions of serous, neovascular and fibrous tissue. PEDCI for each component was calculated using the formula (component area/PED area)x100%. Other OCT parameters: PED height, width, central macular thickness (CMT), neurosensory detachment height (NSD-h), choroidal thickness were manually measured by a trained researcher. Repeated measures analysis of variance was used to compare interval changes in various OCT-based parameters during the study duration.

Results : Over time, average PED height decreased by 42.5% (p=0.86), CMT reduced by 65.2µm (p=0.01), and NSD-h declined by 86.5 µm (p<0.01). At baseline, 17 eyes had acute CSCR and 15 eyes had chronic CSCR, and 7/17 acute CSCR eyes had PED, and 8/15 chronic CSCR eyes had PED; PEDCI-N was larger than PEDCI-S on average for both acute and chronic (40.3% vs 17% and 30.5% vs 0%, respectively). At 12-month follow-up, 6/7 of acute CSCR group had PED, and 6/8 chronic CSCR group had PED; PEDCI-S was largest for acute CSCR (53.4%) and PEDCI-N was largest for chronic CSCR (46.7%).

Conclusions : We report changes in PED characteristics and identify a novel biomarker (PEDCI) to differentiate serous and neovascular components in PEDs in CSCR with higher PEDCI-S in acute CSCR, and higher PEDCI-N in chronic CSCR. Future studies will analyze this biomarker over longer follow-up periods to monitor disease progression and treatment response. Correlations with other imaging modalities can aid in validating this method.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Acute vs Chronic CSCR PED Compartments labeled (more serous PED component in acute, more neovascular/fibrous PED components in chronic)

Acute vs Chronic CSCR PED Compartments labeled (more serous PED component in acute, more neovascular/fibrous PED components in chronic)

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