June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Analysis of progressing geographic atrophy in dry age-related macular degeneration with reticular pseudodrusen
Author Affiliations & Notes
  • Jae Hyup Lee
    ophthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • Chang Ki Yoon
    ophthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • KunHo Bae
    ophthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • Taffeta Ching Ning Yamaguchi
    Boehringer Ingelheim International GmbH, Ingelheim, Rheinland-Pfalz, Germany
  • Rolf Herrmann
    Boehringer Ingelheim International GmbH, Ingelheim, Rheinland-Pfalz, Germany
  • Footnotes
    Commercial Relationships   Jae Hyup Lee None; Chang Ki Yoon None; KunHo Bae None; Taffeta Ching Ning Yamaguchi None; Rolf Herrmann None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2166. doi:
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      Jae Hyup Lee, Chang Ki Yoon, KunHo Bae, Taffeta Ching Ning Yamaguchi, Rolf Herrmann; Analysis of progressing geographic atrophy in dry age-related macular degeneration with reticular pseudodrusen. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2166.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate geographic atrophy (GA) progression in dry age-related macular degeneration (AMD) with reticular pseudodrusen (RPD) and the association with change of retinal sensitivity

Methods : This was a retrospective cohort study of patients with dry AMD, presenting geographic atrophy and reticular pseudodrusen in at least one eye and were imaged with sequential fundus autofluorescence (FAF) or optical coherence tomography (OCT) and macular analyzer integrity assessment (MAIA) microperimetry. Geographic atrophy progression, evaluated with FAF or cirrus OCT images, was measured in macular region and factors associated with GA progression were evaluated. Changes of average threshold in MAIA microperimetry and visual acuity were also measured and its association with GA progression was analyzed.

Results : The study sample included 116 eyes of 81 patients. At baseline, 95.7% of eyes had RPD, and the average GA progression rate was 1.52 mm2/y (SD 1.33) and 1.34 mm2/y (SD 1.54) on FAF and Cirrus OCT images, respectively (p=0.549). GA progression was significantly faster in the eyes with RPD (1.91 mm2/y, SD 1.60) (p=0.009), and patients in the lower 50th percentile of baseline GA area had a lower progression rate than patients in the upper 50th percentile (1.17 mm2/y vs. 2.48 mm2/y, p= 0.001). Additionally, regression analysis showed that baseline GA area was significantly associated with GA progression rate in patients with RPD (p=0.029). Positive correlation was observed between GA progression and change of retinal sensitivity on MAIA microperimetry (p=0.016), and presence of ribbon type RPD was closely associated with the retinal sensitivity alteration (p=0.020).

Conclusions : Presence of RPD and larger GA area at baseline in dry AMD patients suggest possible influence on high GA expansion rate. Retinal sensitivity may decrease more when the ribbon type RPD is dominant in the case of dry AMD with RPD.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. (A, B) Measuring the area of hypertransmission in 5mm radius circle by advanced RPE analysis software on Cirrus OCT. (C, D) Measuring the area of hypofluorescence in 6mm radius circle on FAF segmentation tool, subtracted 1mm radius circle.

Figure 1. (A, B) Measuring the area of hypertransmission in 5mm radius circle by advanced RPE analysis software on Cirrus OCT. (C, D) Measuring the area of hypofluorescence in 6mm radius circle on FAF segmentation tool, subtracted 1mm radius circle.

 

Figure 2. Histogram of GA progression rates per year in dry AMD patients examined by both Cirrus OCT and Heidelberg FAF imaging. Mean GA progression rates were 1.52 ± 1.33 mm2/y and 1.34 ± 1.54 mm2/y in FAF imaging and Cirrus OCT, respectively.

Figure 2. Histogram of GA progression rates per year in dry AMD patients examined by both Cirrus OCT and Heidelberg FAF imaging. Mean GA progression rates were 1.52 ± 1.33 mm2/y and 1.34 ± 1.54 mm2/y in FAF imaging and Cirrus OCT, respectively.

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