Abstract
Purpose :
To determine the diagnostic ability of specific corneal tomography indices to detect corneal ectasia using a swept-source optical coherence tomography system (SS-OCT, ANTERION, Heidelberg Engineering, Germany) and a rotating Scheimpflug camera system (RSC, Pentacam HR, Oculus, Germany).
Methods :
This was a prospective, observational, and cross-sectional study. The inclusion criteria for healthy eyes (group 1) were a maximal keratometry value < 47 D, inferior-superior value < 1.5 D, and KISA% < 60. Group 2 included one eye of a bilateral clinical keratoconus (KC). Group 3 included eyes with normal topography (maximal keratometry value < 47 D, inferior-superior value < 1.5 D, and KISA% < 60), where the contralateral eye showed a clinical keratoconus. The eyes of group 3 were considered as very early ectasia. Exclusion criteria were previous ocular surgeries and other ocular pathologies. The main outcome measure was the area under the curve (AUC) of the ROC analysis of the Belin/Ambrosio total deviation value (BAD D) and the Pentacam Random Forest Index (PRFI) provided by RSC compared to the SCORE parameter provided by the SS-OCT. Statistical analysis was performed using the DeLong test.
Results :
A total of 354 eyes of 354 subjects were included (group 1: 90, group 2: 209, and group 3: 55). The median of BAD D, PRFI, and SCORE was 0.99, 0.05, and -1.69 for group 1; 7.82, 0.99, and 16.53 for group 2; and 1.46, 0.24, and 0.6 for group 3, respectively (all P < 0.05). When separating group 3 from group 1, the ROC analysis revealed a statistical significant higher AUC for the SCORE parameter (0.894) compared to PRFI (0.783, P < 0.05) and BAD D (0.727, P < 0.05). The sensitivity and specificity was 76 %/87% (SCORE) compared to 58%/90% (PRFI), and 47%/91% (BAD D). When distinguishing group 1 from both ectatic subgroups (group 2 and 3), the AUC was 0.981, 0.961, and 0.948 for SCORE, PRFI, and BAD D (all P < 0.05).
Conclusions :
The SCORE parameter provided by SS-OCT yielded the highest AUC and therefore the best diagnostic ability to detect corneal ectasia. A clinical acceptable sensitivity and specificity was found for SCORE to distinguish normal eyes (group 1) from very early ectasia (group 3).
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.