Abstract
Purpose :
Microperimetry has been discussed as a potential study endpoint for eyes with early disease due to the possibility to detect subclinical changes. We investigated the test-retest repeatability of pointwise retinal sensitivity (PWS) between two microperimetry devices with each two repeated examinations in healthy subjects as well as patients with early and intermediate age-related macular degeneration (iAMD).
Methods :
Healthy age-matched eyes as well as eyes with early or intermediate received two successive microperimetry examinations on both MP3 (Nidek Co, Japan) and MAIA (CenterVue, Italy). The sequence of devices was randomized and groups were stratified to avoid any device sequence-related bias. A mandatory break of ten minutes was taken between examinations to minimize weariness. Repeatability was assessed by using Bland-Altman plots and intraclass correlation coefficient (ICCs). A mixed model was calculated to evaluate impact on PWS.
Results :
Seven thousand two hundred microperimetry stimuli were acquired from 40 eyes. Twenty eyes were from healthy subjects (70.2 ±10.6 years) and 20 from patients with iAMD (76.2 ±6.9 years). Mean (±SD) PWS for MAIA examinations were 25.5 ±2.8 dB for healthy subjects and 22.6 ±3.7 dB for subjects with iAMD. PWS for the MP3 examinations were 29.2 ±2.6 dB and 26.2 ±3.4 for healthy and iAMD subjects, respectively. Bland-Altman plots showed in healthy eyes (CoR95 ±4.6dB, MAIA; ±4.4dB, MP3) and in iAMD patients (CoR95 ±5.2dB, MAIA; ±4.6dB, MP3). The ICC for the device specific PWS of MAIA and MP3 is 0.68 and 0.75 for healthy and for iAMD subjects, respectively. The mixed model showed a significant effect for age (-0.07 dB/year, p<0.001) and eccentricity (-0.274 dB/°, p<0.001). The PWS in healthy aged eyes related to iAMD had no significant difference (p=0.497) on PWS. The interaction diagnosis*excentricity (p<0.001) had a significant impact whereas the interaction age*diagnosis (p=0.538) had not.
Conclusions :
The MP3 as well as MAIA show an adequate intradevice test-retest repeatability for PWS as well as a moderate positive interdevice correlation. Collectively both healthy and iAMD patients scored at a high level throughout the examinations with only a trend for inferior performance in iAMD indicating no significant loss of retinal sensitivity in early AMD stages.
This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.