June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Volumetric montage for large field of view optical coherence tomography angiography scans
Author Affiliations & Notes
  • Warren Lewis
    Bayside Photonics, Inc, Yellow Springs, Ohio, United States
  • Luis De Sisternes
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Sophie Kubach
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Nadia K Waheed
    Tufts University School of Medicine, Boston, Massachusetts, United States
    New England Eye Center, Boston, Massachusetts, United States
  • Jean-Francois Korobelnik
    Service d'Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux Groupe hospitalier Pellegrin, Bordeaux, Aquitaine, France
    Bordeaux Population Health, Universite de Bordeaux College Sciences de la Sante, Bordeaux, Aquitaine, France
  • Manon Nailly
    Assistance Publique - Hopitaux de Paris, Paris, Île-de-France, France
    Hopital Lariboisiere Service d'Ophtalmologie, Paris, Île-de-France, France
  • Aude Couturier
    Universite Paris Cite, Paris, Île-de-France, France
    Hopital Lariboisiere Service d'Ophtalmologie, Paris, Île-de-France, France
  • Sophie Bonnin
    La Fondation Adolphe de Rothschild, Paris, Île-de-France, France
  • Ramin Tadayoni
    Universite Paris Cite, Paris, Île-de-France, France
    Hopital Lariboisiere Service d'Ophtalmologie, Paris, Île-de-France, France
  • Footnotes
    Commercial Relationships   Warren Lewis Carl Zeiss Meditec, Inc., Code C (Consultant/Contractor); Luis De Sisternes Carl Zeiss Meditec, Inc., Code E (Employment); Sophie Kubach Carl Zeiss Meditec, Inc., Code E (Employment); Nadia Waheed Nidek Medical Products, Boehringer Ingelheim, Topcon, Code C (Consultant/Contractor), AGTC, Code E (Employment), Carl Zeiss Meditec, Inc., Heidelberg, Nidek Medical Products, Topcon, Code F (Financial Support), Ocudyne, Code I (Personal Financial Interest), Gyroscope Therapeutics, Code S (non-remunerative); Jean-Francois Korobelnik Allergan-Abbvie, Apellis, Bayer, Janssen, NanoRetina, Roche, Thea, Carl Zeiss Meditec, Inc., Code C (Consultant/Contractor), Alexion, Novonordisc, Code S (non-remunerative); Manon Nailly None; Aude Couturier Abbvie, Alcon, Bayer, Horus, Novartis, Roche, Code F (Financial Support); Sophie Bonnin None; Ramin Tadayoni AbbVie Allergan, Alcon, Apellis, Bayer, Genentech, Iveric Bio, KHB, Novartis, Oculis, Roche, Thea, Code C (Consultant/Contractor), AbbVie Allergan, Alcon,Bayer, Boehringer Ingelheim, Novartis, Carl Zeiss Meditec, Inc., Code F (Financial Support), AbbVie Allergan,Bayer, Genentech, KHB, Novartis, Oculis, Roche, Code R (Recipient)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3389. doi:
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      Warren Lewis, Luis De Sisternes, Sophie Kubach, Nadia K Waheed, Jean-Francois Korobelnik, Manon Nailly, Aude Couturier, Sophie Bonnin, Ramin Tadayoni; Volumetric montage for large field of view optical coherence tomography angiography scans. Invest. Ophthalmol. Vis. Sci. 2023;64(8):3389.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate whether high resolution large field of view (FOV) volumetrically montaged 15x15mm optical coherence tomography angiography (OCTA) scans could provide the visualization of both the macula and extended periphery in one single volume. Unlike the case with 2D montage, continuous B-scans across the composite FOV may be referred to the montaged en face images for easier location and interpretation of visible features.

Methods : Pairs of 15x15mm x 6mm deep OCTA scans were obtained using PLEX® Elite 9000 (ZEISS, Dublin, CA) with nasal and temporal fixations offset by 15 degrees from the center. See Figure 1. First, a slab-based distortion-corrected montage was created using existing 2D compositing methods. Maps of point locations in each constituent 2D image were used to interpolate the points in the new volume. The depth registration of the two constituent volumes enabled identification of the appropriate voxels in these volumes that should contribute to each voxel in the combined volume. Lookup tables generated from the slab montage were used to calculate the value of each voxel in the output volume.
30 pairs of 15x15mm scans of 30 unique eyes from 19 subjects with varying degrees of diabetic retinopathy (DR), and with 15 degree nasal and temporal fixation offsets were obtained. An experienced clinician evaluated each scan and assigned it a quality score from 1 (worst) – 5 (best) by evaluating the full retina en face and the B-scans. The corresponding montages were also graded for quality according to the same criteria used for the inputs. The quality of the output was then compared with the two inputs to check for clinically significant loss of quality.

Results : For the 30 pairs of images that were volume montaged, no montage was rated lower in quality than the lesser of the two inputs.

Conclusions : Montaging offset 15x15mm OCTA scans, resulting in an approximately 15mm(V) x 24mm(H) x 6mm(D) FOV, enables high resolution visualization of the periphery as well as the macula in a single volume, with no loss of image quality.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Figure 1. Two laterally offset scans (above) were montaged to a single volume (middle). The combined volume may be sliced as desired to yield B-scans (below)

Figure 1. Two laterally offset scans (above) were montaged to a single volume (middle). The combined volume may be sliced as desired to yield B-scans (below)

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