June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
The association of physical activity with glaucoma and related traits in the UK Biobank
Author Affiliations & Notes
  • Kian Madjedi
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
    Ophthalmology, University of Calgary, Calgary, Alberta, Canada
  • Kelsey Vernon Stuart
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Sharon Chua
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Pradeep Y Ramulu
    Johns Hopkins Medicine Wilmer Eye Institute, Baltimore, Maryland, United States
  • Alasdair Warwick
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Robert Luben
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Zihan Sun
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Mark Chia
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Hughes Aschard
    Department of Computational Biology, Institut Pasteur, Paris, Île-de-France, France
  • Janey L Wiggs
    Harvard Medical School, Boston, Massachusetts, United States
  • Jae H Kang
    Channing Division of Network Medicine, Harvard Medical School, Boston, Massachusetts, United States
  • Louis R Pasquale
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Paul Foster
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Anthony P Khawaja
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships   Kian Madjedi None; Kelsey Stuart None; Sharon Chua None; Pradeep Ramulu None; Alasdair Warwick None; Robert Luben None; Zihan Sun None; Mark Chia None; Hughes Aschard None; Janey Wiggs None; Jae Kang None; Louis Pasquale None; Paul Foster None; Anthony Khawaja None
  • Footnotes
    Support  KVS, Fight for Sight London (1956A); AW, Wellcome Trust (220558/Z/20/Z); PJF, unrestricted grant from Alcon; APK, UK Research and Innovation Future Leaders Fellowship, Alcon Research Institute Young Investigator Award, Lister Institute for Preventive Medicine Award; RNL Moorfields Eye Charity Springboard Award; LRP NEI EY015473, EY032559, unrestricted Challenge Grant from Research to Prevent Blindness (NYC); The Glaucoma Foundation (NYC). A proportion of our financial support from the UK Department of Health through an award made by the National Institute for Health Research to Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology for a Biomedical Research Centre for Ophthalmology
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2904. doi:
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    • Get Citation

      Kian Madjedi, Kelsey Vernon Stuart, Sharon Chua, Pradeep Y Ramulu, Alasdair Warwick, Robert Luben, Zihan Sun, Mark Chia, Hughes Aschard, Janey L Wiggs, Jae H Kang, Louis R Pasquale, Paul Foster, Anthony P Khawaja; The association of physical activity with glaucoma and related traits in the UK Biobank. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2904.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Physical activity (PA) is well-established to be protective against various chronic diseases but evidence for its association with glaucoma is unclear. We conducted cross-sectional and gene-environment interaction analyses of UK Biobank participants to assess the association of PA with glaucoma and related traits.

Methods : Participants with data on self-reported (International Physical Activity Questionnaire) (N1) or accelerometer-derived PA (N2) and corneal-compensated intraocular pressure (IOP) (N1=94 206; N2=27 777); macular inner retinal OCT measurements (N1=36 274; N2=9 991); and glaucoma status (N=86 803; N2=23 556) were classified according to PA level. Ocular parameters were measured as part of an eye examination and glaucoma case ascertainment was through self-report and linked national hospital records. We evaluated multivariable associations of PA with IOP and macular inner retinal OCT parameters using linear regression, and with glaucoma status using logistic regression, adjusting for key socioeconomic, demographic, and lifestyle variables. We examined gene-PA interactions using a glaucoma polygenic risk score consisting of 2 673 variants.

Results : In multivariable-adjusted regression models, we found no association between overall PA level or greater duration of time spent in PA and glaucoma status. Higher overall PA levels and greater time spent in higher levels of both self-reported and accelerometry-derived PA were positively associated with thicker mGCIPL (Ptrend <0.001 for all). Compared to participants in the lowest quartile of PA, those in the highest quartiles of accelerometry-derived moderate and vigorous intensity PA had a thicker mGCIPL(μm) by +0.57(P<0.001) and +0.42(P=0.005). No associations were found with mRNFL thickness. High overall level of self-reported PA was associated with a modestly higher IOP (+0.08mmHg(P=0.010) but this was not replicated in the accelerometry data. No associations were modified by level of underlying genetic risk for glaucoma (Pinteraction all >0.05).

Conclusions : On a population level, higher overall PA level and greater time spent in moderate and vigorous PA were not associated with glaucoma status, but were positively associated with a thicker mGCIPL. We found no evidence that high levels of habitual PA are associated with glaucoma or IOP in the general population.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Difference in OCT parameter thickness by time spent in various levels of PA

Difference in OCT parameter thickness by time spent in various levels of PA

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