June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Volume-Rendering Three-Dimensional Image Analysis of Macular Neovascularization in Age-Related Macular Degeneration
Author Affiliations & Notes
  • mihyun choi
    Korea University, Seongbuk-gu, Korea (the Republic of)
  • Seong-woo kim
    Korea University, Seongbuk-gu, Korea (the Republic of)
  • cheolmin yun
    Korea University, Seongbuk-gu, Korea (the Republic of)
  • Jaeryung Oh
    Korea University, Seongbuk-gu, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   mihyun choi None; Seong-woo kim None; cheolmin yun None; Jaeryung Oh None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2161. doi:
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      mihyun choi, Seong-woo kim, cheolmin yun, Jaeryung Oh; Volume-Rendering Three-Dimensional Image Analysis of Macular Neovascularization in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2161.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To visualize and investigate the three-dimensional (3D) images of macular neovascularization (MNV) in eyes with neovascular age-related macular degeneration using optical coherence tomography angiography (OCTA) according to the treatment response to intravitreal aflibercept injection (IVI).

Methods : OCTA images at baseline and 12 weeks (after three loading IVIs) were retrospectively reconstructed as 3D images for patients with type 1 and 2 MNVs treated with the “pro-re-nata” regimen. The dry-up and remnant fluid groups were divided according to the presence of subretinal and intraretinal fluid at 12 weeks after treatment. Using reconstructed 3D images of MNVs, the volume, average volume per slice, and z-axis of the volumetric structure were evaluated.

Results : Twenty-three and nine were classified into the dry-up and remnant fluid groups, respectively. The MNV volume decreased significantly from baseline to 12 weeks in the dry-up group (p = 0.005), not in the remnant fluid group (p = 0.250). The average volume of MNVs per slice at 12 weeks correlated with the remnant fluid group in both the univariate and multivariate analyses (p = 0.034, p = 0.039, Exp [B] = 14.005).

Conclusions : This study may provide a perspective on vascular volumetric changes of MNVs according to treatment response.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

Enface image of optical coherence tomography angiography (OCTA) and three-dimensional (3D) reconstructed macular neovascularization (MNV) image from the dry-up group. (A-D)

Enface image of optical coherence tomography angiography (OCTA) and three-dimensional (3D) reconstructed macular neovascularization (MNV) image from the dry-up group. (A-D)

 

Enface image of optical coherence tomography angiography (OCTA) and three-dimensional (3D) reconstructed macular neovascularization (MNV) image from the remnant fluid group. (A-D)

Enface image of optical coherence tomography angiography (OCTA) and three-dimensional (3D) reconstructed macular neovascularization (MNV) image from the remnant fluid group. (A-D)

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