June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Contrast Sensitivity Better Differentiates Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity
Author Affiliations & Notes
  • Jack Tracy
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Grace Baldwin
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Mary Munsell
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Filippos Vingopoulos
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Hanna Choi
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Itika Garg
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Rachel Tandias
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Hannah Wescott
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Matthew Finn
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Augustine Bannerman
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Rebecca Zeng
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Demetrios G. Vavvas
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Deeba Husain
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Leo A Kim
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Nimesh Patel
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • John B Miller
    Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Jack Tracy None; Grace Baldwin None; Mary Munsell None; Filippos Vingopoulos None; Hanna Choi None; Itika Garg None; Rachel Tandias None; Hannah Wescott None; Matthew Finn None; Augustine Bannerman None; Rebecca Zeng None; Demetrios Vavvas Valitor, Olix Pharmaceuticals, Code C (Consultant/Contractor), National Eye Institute, National Institute of Health (R01EY025362 and R21EY0203079), Research to Prevent Blindness, Loeffers Family Foundation, Yeatts Family Foundation, Alcon Research Institute, Code F (Financial Support); Deeba Husain Allergan, Genentech, Omeicos Therapeutics, Code C (Consultant/Contractor), National Eye Institute, Lions VisionGift, Commonwealth Grant, Lions International, Syneos LLC, The Macular Society, Code F (Financial Support); Leo Kim 11229662, WO2019099595, Code P (Patent); Nimesh Patel Alimera Sciences, Alcon, Allergan, Genentech, Eyepoint, Lifesciences Guidepoint, GLG, Code C (Consultant/Contractor), Retina Innovation Fund, Massachusetts Eye and Ear, Boston, MA, Code F (Financial Support); John Miller Alcon, Topcon, Allergan, Carl Zeiss, Sunovion, Genentech, Code C (Consultant/Contractor)
  • Footnotes
    Support  RM - Funded Agreement with Massachusetts Lions Eye Research Fund, Inc.; RM - Research SUNDRY
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5335. doi:
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      Jack Tracy, Grace Baldwin, Mary Munsell, Filippos Vingopoulos, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew Finn, Augustine Bannerman, Rebecca Zeng, Demetrios G. Vavvas, Deeba Husain, Leo A Kim, Nimesh Patel, John B Miller; Contrast Sensitivity Better Differentiates Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5335.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aimed to evaluate the associations between wide-field swept-source optical coherence tomography angiography (WF SS-OCTA) metrics with visual acuity (VA) and contrast sensitivity (CS) among healthy eyes.

Methods : This cross-sectional study has 57 eyes of 45 patients from May 2019 to April 2022 who had same day VA, CS, and OCTA. Median age was 61 (52 - 65) years. Median logMAR VA was 0 (0 - 0). Eyes were imaged with WF SS-OCTA (PLEX Elite 9000, Carl Zeiss Meditec) and tested with Quantitative CS function (qCSF, Adaptive Sensory Technology). Functional outcomes included Snellen VA, and the CS metrics: Area under the Log CSF (AULCSF), contrast acuity (CA), and contrast sensitivity (CS) thresholds at 1 to 18 cycles per degree (cpd). The ARI Network (Zeiss Portal v5.4) quantified vessel density (VD) and vessel skeletonized density (VSD) in the superficial (SCP) and deep (DCP) capillary plexus and whole retina (WR), and foveal avascular zone (FAZ) area, circularity, and perimeter on 3, 6, and 12 mmxmm OCTA images. Mixed effects multivariable regression analyses were performed (p<0.05) using backward stepwise elimination.

Results : Multivariable regression results, controlling for age, lens status, and laterality, revealed that VA was significantly associated with FAZ area (β = -0.35, p = 0.040) and perimeter (β = -0.07, p = 0.022) on 3mmxmm scans but did not have significant associations with vascular metrics on 6 and 12 mmxmm images. Multiple CS metrics were significantly associated with OCTA vascular metrics on all three image sizes. For example, VD and VSD in the DCP on 12 mmxmm images was significantly associated with AULCSF (β = 0.82, p = 0.036; β = 0.02, p = 0.028, respectively) and CS at 6 cpd (β = 0.97, p = 0.040; β = 0.03, p = 0.032), 12 cpd (β = 1.36, p = 0.011; β = 0.04, p = 0.008), and 18 cpd (β = 1.17, p = 0.007; β = 0.03, p = 0.006).

Conclusions : Our results revealed significant associations between CS and WF SS-OCTA among healthy eyes, suggesting that CS is a sensitive visual function metric that likely reflects retinal microvasculature differences not detected by Snellen VA. Using CS in routine clinical practice may help screening for retinal diseases, particularly given the rising myopia epidemic and aging population, and improve understanding of how retinal microvasculature influences visual function.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

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