June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Incidence and Complications of Silicone Oil Emulsification After Vitrectomy for Complex Retina Diseases: Comparison of 1000- versus 5000-centistoke Silicone Oil
Author Affiliations & Notes
  • Joseph Domenic DeSimone
    Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • John E Williamson III
    Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • Raziyeh Mahmoudzadeh
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Taku Wakabayashi
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Hannah Elise Anderson
    Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • Charles DeYoung
    Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • Ajay C Makkena
    Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • Mirataollah Salabati
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Rebecca Soares
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Jason Hsu
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Sonia Mehta
    Retina Service, Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Joseph DeSimone None; John Williamson III None; Raziyeh Mahmoudzadeh None; Taku Wakabayashi None; Hannah Anderson None; Charles DeYoung None; Ajay Makkena None; Mirataollah Salabati None; Rebecca Soares None; Jason Hsu None; Sonia Mehta None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4548. doi:
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      Joseph Domenic DeSimone, John E Williamson III, Raziyeh Mahmoudzadeh, Taku Wakabayashi, Hannah Elise Anderson, Charles DeYoung, Ajay C Makkena, Mirataollah Salabati, Rebecca Soares, Jason Hsu, Sonia Mehta; Incidence and Complications of Silicone Oil Emulsification After Vitrectomy for Complex Retina Diseases: Comparison of 1000- versus 5000-centistoke Silicone Oil. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4548.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare incidence and complications of silicone oil (SO) emulsification after vitrectomy with 1000- or 5000-centistoke SO tamponade for complex retinal diseases.

Methods : We retrospectively reviewed the medical records of consecutive series of patients who underwent vitrectomy using 1000-centistoke (SO1000) or 5000-centistoke silicone oil (SO5000) at Wills Eye Hospital between January 2012 and January 2021. Baseline characteristics, including demographic information, underlying pathologies, vitreous hemorrhage, and the extent of proliferative vitreoretinopathy (PVR) were collected. The primary outcome was the incidence of SO emulsification after SO1000 vs. SO5000. Secondary outcomes included the time to SO emulsification and complications such as ocular hypertension and re-operation.

Results : A total of 2812 eyes (2724 patients) received SO tamponade; 2619 eyes were treated with SO1000 and 184 eyes with SO5000. Rates of vitreous hemorrhage at baseline were similar between groups (P=.95). Indications for SO tamponade were as follows: recurrent rhegmatogenous retinal detachment (RRD) with PVR (37%), primary RRD with PVR (20%), diabetic tractional retinal detachment (18%), primary RRD without PVR (12%), recurrent RRD without PVR (8%), trauma (3%) and other (2%). The overall incidence of SO emulsification was 7.25% per eye (204/2812 eyes) and 5.40% per injection (204/3759 injections). Based on the SO type, the incidence of emulsification per injection was 5.47% (185/3379) in the SO1000 group, and 4.99% (18/361) in the SO5000 group (P=.79). The mean time (±SD) to emulsification was 481±472 days in the SO1000 group and 788±592 days in the SO5000 group (P=.046). In eyes with SO emulsification, 31% had ocular hypertension and 41% required topical medications to manage intraocular pressure. In 45% of eyes with SO emulsification, there were emulsified oil droplets in the anterior chamber. There were no differences in complication rates between SO1000 and SO5000 (all P>.05).

Conclusions : This analysis is the largest study to examine the incidence and complications of SO emulsification after SO1000 and SO5000. The incidence of emulsification and complications did not differ significantly between SO1000 and SO5000. SO emulsification was not associated with the number of SO injections nor the presence of vitreous hemorrhage prior to surgery.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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