June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Value of and 24-2 and 10-2 visual field testing for determining central glaucomatous visual field progression
Author Affiliations & Notes
  • Dominique Salh
    Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Oksana Dyachok
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Michael West
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Glen Sharpe
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Corey A Smith
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Paul Rafuse
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Lesya M Shuba
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Marcelo Nicolela
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Balwantray C Chauhan
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Footnotes
    Commercial Relationships   Dominique Salh None; Oksana Dyachok None; Michael West None; Glen Sharpe None; Corey Smith None; Paul Rafuse Allergan Inc., Bausch and Lomb, Code R (Recipient); Lesya Shuba None; Marcelo Nicolela Allergan Inc., Heidelberg Engineering, Code F (Financial Support), Bausch and Lomb, Code R (Recipient); Balwantray Chauhan Heidelberg Engineering, iCare, Topcon Inc., Code F (Financial Support), iCare, Code R (Recipient)
  • Footnotes
    Support  Canadian Institutes of Health Research grant PJT-159564, Gordan and Jean Hayman Glaucoma Research Studentship
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5506. doi:
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      Dominique Salh, Oksana Dyachok, Michael West, Glen Sharpe, Corey A Smith, Paul Rafuse, Lesya M Shuba, Marcelo Nicolela, Balwantray C Chauhan; Value of and 24-2 and 10-2 visual field testing for determining central glaucomatous visual field progression. Invest. Ophthalmol. Vis. Sci. 2023;64(8):5506.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the relative merit of the 10-2 test compared to the central points of the 24-2 test in determining progression in early glaucoma.

Methods : We obtained data from a prospective follow-up study on the value of central visual field imaging and perimetry with a cohort of patients with early open-angle glaucoma and healthy control subjects. All subjects were tested with both tests every 4 months. We included those subjects with ≥5 pairs of tests and then selected only the central 12 test locations of the 24-2 test and all 68 locations of the 10-2 test for further analysis. We conducted a regression analysis of global and quadrant mean deviation, and of pointwise total deviation values. We used the area under the receiver operating characteristics curve (AUC) for determining performance.

Results : The study contained 92 glaucoma patients and 52 healthy controls with mean age of 68 and 64 years, respectively. Patients and controls had a median follow-up of 4.1 (with 11 tests) and 3.9 (with 9 tests) years, respectively. There was no difference in the 24-2 and 10-2 AUC in global analysis (difference=-0.025, CI=-0.098, 0.049). Similar results were found in quadrant analysis with differences in AUC ranging from -0.040 to 0.067, each with CIs including 0. With specificity fixed at 90% to determine a cut-off slope for progression, most patients were identified with both tests (Fig. 1), however, the overlap was lower in quadrant analysis, with the 10-2 test identifying more progressing patients in the superior field and the 24-2 test more in the inferior field. When the criterion for progression was the number of progressing points at different slopes, the AUC for the 10-2 test was significantly higher for slopes ≤ -0.75 dB/y (Fig. 2).

Conclusions : The ability of the central 24-2 and 10-2 tests to detect progression in global and quadrant analysis was comparable. However, we provide empirical evidence that adding the 10-2 test may be beneficial when fast progression in individual points in the 24-2 test is detected.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

 

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