June 2023
Volume 64, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2023
Correlation of Retinal Nonperfusion on Ultrawide Field Fluorescein Angiography to Retinopathy Severity and Macular Edema in Diabetic Eyes
Author Affiliations & Notes
  • Recivall Salongcay
    Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
    Eye and Vision Institute, The Medical City, Pasig City, Metro Manila, Philippines
  • Lizzie Anne Aquino
    Philippine Eye Research Institute, University of the Philippines Manila National Institutes of Health, Manila, Metro Manila, Philippines
  • Claude Michael Salva
    Philippine Eye Research Institute, University of the Philippines Manila National Institutes of Health, Manila, Metro Manila, Philippines
  • Tunde Peto
    Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
  • Paolo S Silva
    Joslin Diabetes Center Beetham Eye Institute, Boston, Massachusetts, United States
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Recivall Salongcay None; Lizzie Anne Aquino None; Claude Michael Salva None; Tunde Peto Novartis, Bayer, Roche, Heidelberg, Optos, Code C (Consultant/Contractor), Optomed, Optos , Code F (Financial Support); Paolo Silva Optomed, Optos , Code F (Financial Support), Novartis, Bayer, Roche, Optos, Optomed , Code R (Recipient)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2381. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Recivall Salongcay, Lizzie Anne Aquino, Claude Michael Salva, Tunde Peto, Paolo S Silva; Correlation of Retinal Nonperfusion on Ultrawide Field Fluorescein Angiography to Retinopathy Severity and Macular Edema in Diabetic Eyes. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2381.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To identify retinal, cones and rods nonperfusion on ultrawide field (UWF) fluorescein angiography (UWF-FA) and determine its correlation to diabetic retinopathy (DR) severity and center-involving diabetic macular edema (ciDME) in diabetic eyes.

Methods : Sixty-nine eyes from 43 patients with diabetes underwent imaging. DR severity was assessed on UWF color photos (UWF-CP) and the presence of ciDME was evaluated using optical coherence tomography (OCT) by 2 independent graders at a centralized reading center. UWF-FA images were segmented into posterior pole (within 10 mm from the foveal center), mid-periphery (10-15 mm) and far periphery (beyond 15 mm), and into macula, within ETDRS and each of the extended peripheral fields (P3-P7) using customizable software measurement tools from the imaging device supplier. Ischemic areas were identified on UWF-FA using Image J software and the nonperfusion index (NPI), cones NPI (CPI) and rods NPI (RPI) within each segmented area of the retina were calculated. Pearson correlation (r) was measured.

Results : DR severity was correlated with NPI in the entire fundus (r=0.55944, p<0.0001) and within all segmented areas of the fundus (r 0.34536 – 0.57411). This remained significant even after distinguishing between cones [CPI: entire fundus (r=0.55617, p<0.0001); all segmented areas (r 0.42368 – 0.59082)] and rods [RPI: entire fundus (r=0.55285, p<0.0001); all segmented areas (r 0.39798 – 0.59311)]. Similarly, the presence of ciDME on OCT is correlated with increasing NPI: entire fundus (r=0.39718, p=0.0014), some segmented areas (r 0.42262 – 0.53961); CPI: entire fundus (r=0.46521, p=0.0001), all segmented areas (r 0.32012 – 0.55029); and RPI: entire fundus (r=0.45586, p=0.0002), all segmented areas (r 0.33034 – 0.53882). The values of the correlation of DR severity and presence of ciDME with NPI, CPI and RPI within each segmented area of the fundus are summarized in Table 1.

Conclusions : Retinal nonperfusion is associated with increasing DR severity and the presence of ciDME. Thus, UWF-FA may potentially be used in identifying eyes at high-risk for developing ciDME and in surveilling DME among patients with diabetes. Detecting the level of retinal ischemia at which point it is likely to threaten vision requires further study.

This abstract was presented at the 2023 ARVO Annual Meeting, held in New Orleans, LA, April 23-27, 2023.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×